Surgical outcome and patterns of recurrence for retroperitoneal sarcoma at a single centre

Annals of the Royal College of Surgeons of England
H D J HoggJ J French

Abstract

Retroperitoneal sarcoma is a surgically managed condition that can recur locally following macroscopically complete resection. Owing to the low incidence of the condition, advances in treatment are reported infrequently but complete compartmental resection and adjuvant or neoadjuvant radiotherapy are areas under investigation. Given the practical difficulty of randomised trials, observational data can highlight advantages from progressive treatment approaches. A retrospective database of consecutive retroperitoneal sarcoma resections performed at a single referral centre between March 1997 and March 2013 was interrogated. Histological, radiological and clinical data were collected. Univariate and multivariate analyses for disease free and overall survival were performed to establish independent predictors of disease recurrence and patient survival. A total of 79 patients underwent 90 resections (63 primary). The mean five-year overall and disease free survival rates were 55.3% and 24.8% respectively. Higher patient age, high tumour grade, presence of extraretroperitoneal disease and invasive tumour phenotype were found to significantly predict survival following multivariate analysis. Half (50%) of the tumours displayed invasiv...Continue Reading

References

Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C YangS A Rosenberg
May 4, 2011·Annals of Surgical Oncology·Chiara MussiVittorio Quagliuolo
Jul 19, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GronchiP G Casali
Mar 1, 2012·Surgical Oncology Clinics of North America·Carol J Swallow, Charles N Catton
Feb 26, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ToulmondeUNKNOWN French Sarcoma Group
Feb 11, 2015·Annals of Surgical Oncology·Sandro PasqualiAnant Desai
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ToulmondeUNKNOWN French Sarcoma Group

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Citations

Jun 12, 2020·Indian Journal of Surgical Oncology·Shraddha PatkarMahesh Goel
Aug 9, 2020·Health and Quality of Life Outcomes·Hui Jun LimMelissa Ching Ching Teo
Jun 20, 2018·The Indian Journal of Surgery·Antonio ChiappaRoberto Biffi

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