Surgical outcome of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis

Epilepsia
Ciğdem OzkaraEmin Ozyurt

Abstract

Seizure outcome in mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) that was evaluated according to a noninvasive protocol was assessed in 165 patients and reported using both Engel's and ILAE classifications. The mean postoperative follow-up was 5.0 +/- 2.7 years. At the end of first year, 77.1% of patients were in Engel-I, and 52.7% were in ILAE-I. Antiepileptic drugs (AEDs) were discontinued in 41 patients (42.7%), all remained seizure-free for >or= 2 years that could be accepted as "cure." Thirty-six patients had recurrences, 19 had running-down phenomena. Anterior temporal lobectomy (ATL) was performed in 27 patients with a better outcome when compared to patients operated by selective anterior hippocampectomy. Clinical risk factors for better and worse outcome, which show some similarity in different reports, seem to veil the main reason, which is the accurate delineation of epileptogenic zone considering the presence of different subgroups and underlying developmental pathologies.

References

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Citations

Nov 11, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yun Jin LeeJoon Soo Lee
Sep 11, 2012·Epilepsia·Rani A SarkisImad M Najm
Jun 1, 2010·Continuum : Lifelong Learning in Neurology·Leslie A Rudzinski, Jerry J Shih
Mar 3, 2012·Neurosurgical Focus·Fernando L ValeSelim R Benbadis
Sep 1, 2012·Epilepsy Research and Treatment·Garima Shukla, Asuri N Prasad
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Meng NaZhiguo Lin
Apr 3, 2010·Seizure : the Journal of the British Epilepsy Association·Orla DunleaNorman Delanty
Jan 11, 2011·Seizure : the Journal of the British Epilepsy Association·Teeradej SrikijvilaikulChaichon Locharernkul
Nov 2, 2014·Journal of Neurosurgery·Johan BjellviKristina Malmgren
Nov 14, 2014·Brain : a Journal of Neurology·Caroline SkirrowTorsten Baldeweg
May 18, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Puneet JainElysa Widjaja

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