Surgical outcomes of pediatric spinal cord astrocytomas: systematic review and meta-analysis

Journal of Neurosurgery. Pediatrics
Tej D AzadGerald A Grant

Abstract

Pediatric spinal astrocytomas are rare spinal lesions that pose unique management challenges. Therapeutic options include gross-total resection (GTR), subtotal resection (STR), and adjuvant chemotherapy or radiation therapy. With no randomized controlled trials, the optimal management approach for children with spinal astrocytomas remains unclear. The aim of this study was to conduct a systematic review and meta-analysis on pediatric spinal astrocytomas. The authors performed a systematic review of the PubMed/MEDLINE electronic database to investigate the impact of histological grade and extent of resection on overall survival among patients with spinal cord astrocytomas. They retained publications in which the majority of reported cases included astrocytoma histology. Twenty-nine previously published studies met the eligibility criteria, totaling 578 patients with spinal cord astrocytomas. The spinal level of intramedullary spinal cord tumors was predominantly cervical (53.8%), followed by thoracic (40.8%). Overall, resection was more common than biopsy, and GTR was slightly more commonly achieved than STR (39.7% vs 37.0%). The reported rates of GTR and STR rose markedly from 1984 to 2015. Patients with high-grade astrocytomas...Continue Reading

References

Jun 1, 1976·Archives of Neurology·T R BrowneG H Roberson
Jun 1, 1976·Journal of Neurosurgery·R SnyderN K Gonatas
Jan 1, 1989·Journal of Neurosurgery·A R CohenF Epstein
Jan 1, 1987·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H H HardisonD A Bruce
Nov 1, 1985·Journal of Neurosurgery·R Reimer, B M Onofrio
Aug 1, 1984·The Journal of Bone and Joint Surgery. British Volume·N CitronD G Thomas
Jan 1, 1993·Acta neurochirurgica·P LunardiA Fortuna
Dec 1, 1996·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G InnocenziA J Raimondi
Oct 1, 1997·Medical and Pediatric Oncology·H Mottl, J Koutecky
Jul 1, 1997·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G J PrzybylskiA J Martinez
Jul 1, 1997·Pediatric Neurosurgery·K Y GohF J Epstein
Dec 5, 1998·Cancer·E BouffetC Mottolese
Aug 25, 1999·Pediatric Radiology·T Young PoussaintN J Tarbell
Apr 15, 2000·Pediatric Neurosurgery·T E MerchantL E Kun
Mar 10, 2004·Pediatric Neurosurgery·Raj Kumar, Vinita Singh
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Sep 25, 2004·Pediatric Blood & Cancer·Nicole TownsendNicholas Foreman
Mar 21, 2008·Journal of Neurosurgery. Pediatrics·Matthew J McGirtGeorge I Jallo
Jul 29, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Salvatore Di MaioPaul Steinbok
Sep 24, 2009·Journal of Neurosurgery. Pediatrics·Katrin ScheinemannUri Tabori
Jul 6, 2010·Arquivos de neuro-psiquiatria·Ricardo de Amoreira GeppEidmar Augusto Neri
May 31, 2011·Bulletin du cancer·Eglantine HulloDominique Plantaz
Jun 22, 2011·Bulletin du cancer·Juliette ThariatLaurent Castillo
Aug 3, 2011·Radiologic Clinics of North America·Maria F Ladino-Torres, Peter J Strouse
Sep 20, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tai-Tong WongFeng-Chi Chang
Nov 10, 2011·Journal of Pediatric Neurosciences·Sandip Chatterjee, Uttara Chatterjee
Feb 7, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chiagozie OnoniwuGeorge Jallo
Mar 27, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Gwi Hyun ChoiKeung Nyun Kim
Jul 10, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sumit BansalAshok Kumar Mahapatra
Feb 23, 2013·Pediatric Neurosurgery·Florian H EbnerMartin U Schuhmann
Feb 26, 2013·International Journal of Radiation Oncology, Biology, Physics·Zachary D GussStephanie A Terezakis
Dec 24, 2013·Journal of Neurosurgery. Pediatrics·Christian SchneiderKarl F Kothbauer
Apr 8, 2014·Journal of Neurosurgery. Pediatrics·Raheel AhmedJames C Torner
Feb 20, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yingjie ZouLi Yang
Jan 1, 2014·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·Iu V Kushel', Iu D Belova
Jun 27, 2015·Journal of Neurosurgery. Pediatrics·Joseph H McAbeePaul Klimo
Nov 12, 2015·Journal of Pediatric Neurosciences·Rajni Kant SahuSanjay Behari
Apr 1, 2017·Journal of Neurosurgery. Pediatrics·Andrew S LuksikGeorge I Jallo
Jun 25, 2017·Neurosurgery·Tej D AzadGerald A Grant

❮ Previous
Next ❯

Citations

Dec 12, 2019·Scientific Reports·Ming ZhangChetan Bettegowda
Dec 4, 2020·Clinical Neurology and Neurosurgery·Scott C SeamanPatrick W Hitchon
Sep 3, 2021·Pediatrics in Review·Victor M Lu, Toba N Niazi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

R

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.