Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: an exploratory analysis in the KANON trial

Osteoarthritis and Cartilage
S LarssonRichard B Frobell

Abstract

Prospectively monitor how treatment of acutely ruptured anterior cruciate ligament (ACL) affects biomarkers of inflammation and proteolytic degradation over 5 years. We studied 119 subjects with acute ACL injury from the randomized controlled knee anterior cruciate ligament, non-surgical versus surgical treatment (KANON)-trial (Clinical trial ISRCTN 84752559) who had synovial fluid, serum and urine samples available from at least two out of six visits over 5 years after acute ACL rupture. All subjects followed a similar rehabilitation protocol where, according to randomization, 60 also had early ACL reconstruction and 59 had the option to undergo a delayed ACL reconstruction if needed. Interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), tumor necrosis factor (TNF), amino acids alanine, arginine, glycine, serine (ARGS)-aggrecan, C-terminal crosslinking telopeptide type II collagen (CTX-II) and N-terminal crosslinking telopeptide type I collagen (NTX-I) were quantified by enzyme-linked immunosorbent assays (ELISA). Subjects randomized to early ACL reconstruction had higher cytokine concentrations in index knee synovial fluid at 4 months (IL-6, IL-8, IL-10, TNF), 8 months (IL-6 and TNF) and at 5 years (IFNγ) compared to thos...Continue Reading

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Citations

May 24, 2019·Arthritis & Rheumatology·Frank W RoemerRichard Frobell
Sep 17, 2019·Medicine and Science in Sports and Exercise·Cale A JacobsChristian Lattermann
Jun 20, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Emily R HuntChristian Lattermann
Dec 7, 2018·Frontiers in Physiology·Staffan LarssonAndré Struglics
Nov 6, 2018·Current Opinion in Rheumatology·Muhammad Farooq RaiLinda J Sandell
Aug 2, 2020·The American Journal of Sports Medicine·Joanna KvistHåkan Gauffin
Jan 22, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Takahiro OguraTakahisa Sasho
Jan 19, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Deborah MasonFiona E Watt
Nov 20, 2019·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Graeme MatthewsonPeter MacDonald
Jul 22, 2020·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Lasun O OladejiJames L Cook
Jul 28, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Constance R Chu
Sep 2, 2021·Nature Reviews. Rheumatology·Armaghan MahmoudianFrank P Luyten
Sep 21, 2021·Sportverletzung Sportschaden : Organ der Gesellschaft für Orthopädisch-Traumatologische Sportmedizin·Frank DiemerTobias Saueressig
Sep 18, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gustavo A OrozcoPetri Tanska
Apr 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huifeng YuanXinwei Han

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