Surgical removal of visceral adipose tissue: effects on insulin action

Current Diabetes Reports
Ilan Gabriely, N Barzilai

Abstract

Many studies have demonstrated that excess of visceral fat has deleterious effects on insulin action. Mainly, it has been shown to be associated with a decrease in hepatic and peripheral insulin sensitivity, which results in a clinical condition also known as insulin resistance. This report describes a novel experimental method that we employed in order to analyze the particular effects of visceral fat on insulin activity. By extracting visceral fat we were able to distinguish the specific role that it plays in insulin action, and to analyze its effects on the gene expression of a variety of fat-derived peptides, which may be considered to be (at least partially) mediators in the development of the metabolic syndrome and possibly diabetes mellitus.

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Citations

Sep 24, 2013·Molecular and Cellular Biochemistry·Muthukrishnan EzhumalaiKodukkur Viswanathan Pugalendi
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Saeid GolbidiIsmail Laher
Jun 29, 2007·AIDS Research and Therapy·Kenneth LichtensteinEric Freedland
Jul 23, 2013·Clinical Interventions in Aging·Sophie CarterFrédéric Picard
Aug 26, 2006·Archives of Physiology and Biochemistry·Luigi LaviolaFrancesco Giorgino
Feb 5, 2011·The Journal of Nutritional Biochemistry·Anna IaconoRosaria Meli
Oct 13, 2009·Clinics in Liver Disease·Wing-Kin SynAnna Mae Diehl
Oct 22, 2008·Trends in Endocrinology and Metabolism : TEM·Herbert Tilg, Alexander R Moschen
Sep 19, 2007·Aging Cell·Nancy J LinfordPeter S Rabinovitch
Sep 6, 2006·Gastroenterology·Herbert Tilg, Gökhan S Hotamisligil
Jun 16, 2005·Diabetes Research and Clinical Practice·Francesco GiorginoAnna Leonardini
Feb 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohamed A El-MoselhyAhmed Fahmy Ahmed
Mar 29, 2006·Diabetes·Luigi LaviolaFrancesco Giorgino
Jun 21, 2016·Cell Metabolism·Elise JefferyMatthew S Rodeheffer
Feb 25, 2014·Journal of Diabetes Research·Saeid Golbidi, Ismail Laher
May 26, 2009·Arquivos brasileiros de endocrinologia e metabologia·Yu WangAimin Xu
Jan 1, 2015·Journal of Diabetes and Metabolic Disorders·Sai Yi PanHoward Morrison
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Jun 13, 2006·Arquivos brasileiros de endocrinologia e metabologia·Fernando F Ribeiro FilhoMaria Teresa Zanella
Apr 20, 2021·Journal of the Endocrine Society·Michael P FranczykJun Yoshino

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