Surgical resection and permanent iodine-125 brachytherapy for brain metastases.

Journal of Neuro-oncology
Kim HuangMichael W McDermott

Abstract

To evaluate the efficacy and toxicity of surgical resection and permanent iodine-125 brachytherapy without adjuvant whole brain radiation therapy (WBRT) for brain metastases. Forty patients were treated with permanent iodine-125 brachytherapy at the time of resection of brain metastases from 1997 to 2003. Actuarial freedom from progression (FFP) and survival were measured from the date of surgery and estimated using the Kaplan-Meier method, with censoring at last imaging for FFP endpoints. The median survival was 11.3 months overall, 12.0 months in 19 patients with newly diagnosed brain metastases and 7.3 months in 21 patients with recurrent brain metastases. Twenty-two patients (55%) remained free of progression of brain metastases, three failed at the resection cavity (including one with leptomeningeal dissemination), two failed with leptomeningeal spread only, and 13 failed elsewhere in the brain including two who also had leptomeningeal disease. The 1-year resection cavity FFP probabilities were 92%, 86% and 88%; and brain FFP probabilities were 29%, 43% and 37% for the newly diagnosed, recurrent and all patients, respectively. Symptomatic necrosis developed 7.4-40.0 months (median, 19.5 months) after brachytherapy in 9 pat...Continue Reading

References

Jun 1, 1978·American Journal of Surgery·J K PatelR H Moore
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L R Coia
Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
Jun 1, 1989·Neurology·L M DeAngelisJ B Posner
Jan 1, 1987·Journal of Neuro-oncology·G E Sheline, L W Brady
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B BorgeltF R Hendrickson
Jul 1, 1982·Journal of the Autonomic Nervous System·M Yoshimura, S Nishi
Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·T L PhillipsI J Weigensberg
Feb 1, 1995·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M BernsteinC Thomason
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·E M NoordijkA R Wattendorff
Jan 1, 1995·British Journal of Neurosurgery·C B Ostertag, F W Kreth
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L GasparR Byhardt
Jul 1, 1997·Journal of Neuro-oncology·M SchulderJ S Loeffler
Nov 11, 1998·JAMA : the Journal of the American Medical Association·R A PatchellB Young
Mar 10, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·T C van der ReeM J van den Bent
Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·P K SneedD A Larson
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·D KondziolkaJ C Flickinger
Dec 22, 1999·American Journal of Clinical Oncology·C NiederK Schnabel
Mar 16, 2004·Journal of Neuro-oncology·M H J SwennenM J B Taphoorn

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Citations

Dec 22, 2009·Journal of Neurosurgery·Zachary A Seymour, Aaron A Cohen-Gadol
Sep 1, 2015·Journal of Neurosurgery·Maximilian I RugeHarald Treuer
Aug 9, 2015·Journal of Neuro-oncology·Hussam Abou Al-ShaarOssama Al-Mefty
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tulika Ranjan, Lauren E Abrey
Jul 2, 2016·Journal of Neurosurgery·David R RaleighMichael W McDermott
Mar 29, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J Travis MendelKaruna M Raj
Jul 21, 2010·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·J Adam CunhaDan Stoianovici
Sep 17, 2011·Journal of Cancer Research and Clinical Oncology·Shengchu ZhangYunxiao Gao
Mar 8, 2012·Radiation Oncology·Silke B SchwarzFriedrich-Wilhelm Kreth
Jan 1, 2013·CNS Oncology·Radhika Dasararaju, Amitkumar Mehta
Jun 28, 2011·Radiation Protection Dosimetry·Sâmia F Brandão, Tarcísio P R Campos
Aug 24, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philipp KarschniaJoerg-Christian Tonn

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