Surgical resection based on ontogenetic cancer field theory for cervical cancer: mature results from a single-centre, prospective, observational, cohort study

The Lancet Oncology
M HöckelLars-Christian Horn

Abstract

Previous findings from our centre suggest that carcinoma of the cervix propagates within ontogenetic cancer fields, tissue compartments defined by staged morphogenesis. We aimed to determine whether surgical treatment that accounts for stage-associated, ontogenetic cancer fields and their associated lymphoid tissues results in locoregional tumour control without the need for adjuvant radiotherapy. We did the final clinical and histopathological evaluation of data from, the single-centre, observational, cohort study, the Leipzig School Mesometrial Resection Study. Patients of any age with stage IB1, IB2, IIA1, IIA2, or IIB cervical cancer (according to 2009 International Federation of Gynecology and Obstetrics [FIGO]) had total mesometrial resection or extended mesometrial resection and therapeutic lymph node dissection, done on the basis of ontogenetic cancer fields. We defined sentinel node, first-line, second-line, and third-line lymph node regions as progressive regional cancer fields. Primary outcomes were disease-specific survival and recurrence-free survival, and treatment-related morbidity (assessed with the Franco-Italian glossary). Applying Cox proportional hazard models, ontogenetic local (T) and regional (N) tumour s...Continue Reading

References

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Jun 14, 2019·Frontiers in Oncology·Michael Höckel, Ulrich Behn

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Citations

Feb 11, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Benjamin WolfMichael Höckel
Aug 31, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alberto Ferreira BonaAnke Bergmann
Oct 16, 2019·Der Pathologe·L-C HornA K Höhn
Aug 7, 2019·The Lancet Oncology·Francesco Raspagliesi, Giorgio Bogani
Aug 19, 2020·Seminars in Cell & Developmental Biology·Thomas E Sharrock, Bénédicte Sanson

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