PMID: 8608500Apr 1, 1996Paper

Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie

Cancer
Bernard NordlingerDaniel Jaeck

Abstract

Five-year survival rates after resection of liver metastases from colorectal carcinoma are close to 25%. Recurrences occur in two-thirds of the patients after surgery. Selection of patients likely to benefit from surgery remains controversial and subjective. Data from 1568 patients with resected liver metastases from colorectal carcinoma were collected. The prognostic value of different factors was studied through uni- and multivariate analyses. A scoring system was developed including the most relevant factors. Two- and 5-year survival rates were 64% and 28%, respectively, and were affected by: age; size of largest metastasis or CEA level; stage of the primary tumor; disease free interval; number of liver nodules; and resection margin. Giving one point to each factor, the population was divided into three risk groups three risk groups with different 2-year survival rates: 0-2 (79%), 3-4 (60%), 5-7 (43%). A simple prognostic scoring system was proposed to evaluate the chances for cure of patients after resection of liver metastases from colorectal carcinoma. The comparison between expected survival and estimated operative risk can help determine on an objective basis whether surgery is worthwhile. This system needs further pros...Continue Reading

Citations

Apr 26, 2014·World Journal of Gastroenterology : WJG·Atsuya TakedaEtsuo Kunieda
Jan 5, 2014·Cancer Immunology, Immunotherapy : CII·Hidetoshi NakagawaShuichi Kaneko
Oct 17, 2008·Future Oncology·Kevin Tri NguyenDavid A Geller
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D C CorsiC Barone
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Ruers, R P Bleichrodt
Aug 26, 1998·Annals of Surgery·J K Seifert, D L Morris
Sep 3, 1999·Journal of the American College of Surgeons·S IwatsukiT E Starzl
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Jan 15, 2000·Annals of Surgery·H UenoT Yamamoto
Oct 20, 2004·Annals of Surgery·Thomas ZachariasJean-Christophe Weber
Nov 25, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·A R Gillams
Jul 19, 2006·World Journal of Surgical Oncology·Bram FiooleInne Hm Borel Rinkes
Aug 2, 2007·Annals of Surgery·Shaheen ZakariaDavid M Nagorney
Aug 2, 2007·Annals of Surgery·Chandrakanth AreMichael D'Angelica
Jun 6, 2009·World Journal of Gastroenterology : WJG·Josep MartíJuan Carlos García-Valdecasas
Jul 1, 2009·International Journal of Biological Sciences·Christoph WilmannsGünther Ruf
Sep 15, 2009·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·K DajaniA Wu
Dec 5, 2009·World Journal of Gastroenterology : WJG·Lei ZhangZe-Jian Huang
Jul 24, 2010·World Journal of Gastroenterology : WJG·Dimitrios DimitroulisGregory Kouraklis
Oct 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J BarthMarc S Ernstoff
Nov 3, 2010·Clinics in Colon and Rectal Surgery·Waleed M Mohammad, Fady K Balaa
Mar 1, 2006·Seminars in Interventional Radiology·J Alexander PalestyJohn F Gibbs
Apr 21, 2011·Current Oncology·F MohamedP Sugarbaker
Aug 5, 2011·Clinical Epidemiology·Morten HøyerJacob Bonde Jacobsen
Aug 27, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Fernando Vidal-Vanaclocha
Jan 3, 2012·World Journal of Surgical Oncology·Kun-Ming ChanJeng-Yi Wang
Jan 10, 2012·World Journal of Gastroenterology : WJG·Guo-Xiang Cai, San-Jun Cai

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