Surgical resection of pulmonary metastases from nasopharyngeal carcinoma

The Australian and New Zealand Journal of Surgery
L C ChengC K Mok

Abstract

Nasopharyngeal carcinoma (NPC), unlike other head and neck cancers,is known for its propensity for distant metastases. Chemotherapy remains the mainstay of treatment because of this and the chemosensitivity of the tumour, but long-term control is rare. The surgical management of pulmonary metastases of other extrathoracic malignancies prompted this review of surgical management of patients with NPC. Thirteen thoracotomies were performed in 12 patients with pulmonary metastases as the first and only site of relapse of nasopharyngeal carcinoma. Postoperative chemotherapy was given in four patients, radiotherapy to the mediastinum in one patient and both chemotherapy and radiotherapy in two patients. The survival pattern of this group of 12 patients was compared with a historical control group consisting of 65 patients without surgical resection. Lymph node involvement was documented in four patients during operation. Four patients relapsed after surgical resection, two of them were from the group of three patients with lymph node involvement. The site of subsequent relapse was the lung for three patients and the skeletal system for the fourth. The 2 year actuarial survival of the surgically resected group compared favourably with...Continue Reading

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Citations

Jun 30, 2004·The Annals of Thoracic Surgery·Masayoshi InoueUNKNOWN Thoracic Surgery Study Group of Osaka University
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Jan 26, 2021·Annals of Surgical Oncology·Ze-Rui ZhaoHao Long
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