Surgical resection of stage IV colorectal cancer and prognosis.

World Journal of Surgery
Hiroshi KatohMasahiko Watanabe

Abstract

Colorectal cancer (CRC) harbors accumulated genetic alterations with cancer progression, which results in uncontrollable disease. To regulate the most malignant CRC, we have to know the most dismal phenotype of stage IV disease. A retrospective review of the Kitasato University Hospital was performed (from 1990 to 2001) to extract the 162 resected stage IV CRC. Clinical variables were tested for their relationship to survival in a multivariate prognostic analysis and revealed the interaction of the prognostic factors. In stage IV CRC with noncurable resection, the most robust univariate predictors for poor prognosis were preoperative high value of CA19-9, peritoneal dissemination, depth of invasion, age, extent of liver metastases, pathologic lymph node metastasis status, and gender as tumor factors, and postoperative therapy, perioperative transfusion, and lymph node dissection extent as treatment factors. Among these factors, postoperative therapy (p < 0.0001), perioperative transfusion (0.0002), CA19-9 (0.001), extent of liver metastases (0.004), and peritoneal dissemination (0.02) were identified as independent prognostic factors by multivariate analysis. Interestingly, among the independent prognostic factors, treatment fa...Continue Reading

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Citations

Mar 13, 2012·International Journal of Colorectal Disease·Manabu ShimomuraHideki Ohdan
Aug 27, 2009·Gastroenterology Research and Practice·Yutaka J KawamuraFumio Konishi
Apr 12, 2013·PloS One·Krystle T PagariganLeslie J Saucedo
Jun 21, 2011·Gastrointestinal Endoscopy Clinics of North America·Alessandro Repici, Daniel de Paula Pessoa Ferreira
Oct 26, 2010·Biochemical and Biophysical Research Communications·Mariko OhtaHiroshi Nakada
Sep 25, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R FragoE Escalante
Jun 16, 2009·The British Journal of Surgery·H KatohM Watanabe
Mar 28, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K YamashitaM Watanabe
Feb 10, 2009·Cancer Science·Keishi Yamashita, Masahiko Watanabe
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Feb 1, 2015·Clinical Orthopaedics and Related Research·Stein J JanssenJoseph H Schwab
Dec 4, 2014·PloS One·Keishi YamashitaMasahiko Watanabe
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May 31, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mohammed AlshareefBruce Frankel

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