Surgical Resection Versus Radiofrequency Ablation for Single Hepatocellular Carcinoma ≤ 2  cm in a Propensity Score Model

Annals of Surgery
Po-Hong LiuTeh-Ia Huo

Abstract

To evaluate the efficacy of surgical resection (SR) and radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC) 2  cm or less. The optimal management for Barcelona Clínic Liver Cancer (BCLC) very early-stage HCC is undetermined. Between 2002 and 2013, a total of 237 (SR, 109; RFA, 128) patients with BCLC very early-stage HCC were enrolled. Their overall survival (OS) and recurrence-free survival (RFS) were compared. Propensity score matching analysis identified 79 matched pairs of patients to compare outcomes. At baseline, patients with SR were younger and had larger tumors (both P < 0.05). The 5-year OS rates were 81% versus 76% (P = 0.136), whereas 5-year RFS rates were 49% versus 24% (P < 0.001) for SR and RFA groups, respectively. In the propensity model, the baseline variables were well balanced between 2 groups. Surgical resection was significantly associated with better OS and RFS compared with RFA; the 5-year OS rates were 80% versus 66% (P = 0.034), and 5-year RFS rates were 48% versus 18% (P < 0.001) for SR and RFA groups, respectively. The Cox proportional hazards model identified RFA as an independent predictor for mortality and tumor recurrence in the propensity model (hazard ratio, 2.120 and 2.421,...Continue Reading

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Citations

Jun 4, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Po-Hong LiuTeh-Ia Huo
Sep 30, 2016·Journal of Hepatology·Alessandro VitaleTimothy M Pawlik
Feb 6, 2017·Journal of Hepato-biliary-pancreatic Sciences·Kenei FurukawaKatsuhiko Yanaga
Nov 22, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Antonio FacciorussoNicola Muscatiello
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Daniel Zamora-ValdesDavid M Nagorney
Feb 23, 2019·Annals of Surgical Oncology·Derek J Erstad, Kenneth K Tanabe
Sep 11, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Shu-Yein HoTeh-Ia Huo
Sep 25, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Hee Ho ChuSung-Gyu Lee
Jun 21, 2019·The Oncologist·Francesco IzzoSteven A Curley
Oct 4, 2016·Journal of Gastroenterology and Hepatology·Po-Hong LiuTeh-Ia Huo
Jun 5, 2018·Annals of Gastroenterological Surgery·Daisuke BanMinoru Tanabe
Nov 5, 2016·Clinical Medicine Insights. Gastroenterology·Jonathan SolderaAndreza Gautério Cavalcanti
Feb 23, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandro Cucchetti, Alessandro Vitale
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Nov 23, 2016·World Journal of Hepatology·Linda L WongJun-Fang Ji
Dec 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Teh-Ia HuoPo-Hong Liu

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

SPSS

Related Concepts

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