Surgical Site Infection in Colorectal Surgery: A Study in Antibiotic Duration

Diseases of the Colon and Rectum
Mark DornfeldDavid W Larson


Despite distant historical studies that demonstrated the adequacy of preoperative antibiotic prophylaxis, current surgical practice continues to use antibiotics for postoperative coverage up to 24 hours. The aim of this study was to evaluate a change in antibiotic prophylaxis duration and its effect on surgical site infection in a high-volume modern colorectal practice. A case-controlled series retrospectively reviewed outcomes through a prospective validated data base. The study was conducted at Mayo Clinic, Rochester, Minnesota. A total of 965 patients were evaluated. Our study analyzed patient outcomes related to surgical site infection comparing cohort 1 (2012-2013), which had the same antibiotic coverage preoperatively up to 24 hours postoperatively, and cohort 2 (2014-2015), which eliminated postoperative doses and relied solely on pre- and intraoperative dosing duration. The primary outcomes of this study are superficial and deep surgical site infection. There were no differences identified for superficial or deep surgical site infection rates between cohorts. Before the change in antibiotic dosing duration (2012-2013), 28 of 493 patients (5.7%) vs after the practice change (2014-2015), 25 of 472 patients (5.3%) were rep...Continue Reading


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Sep 6, 2012·ANZ Journal of Surgery·Byung Kyu Ahn, Kang Hong Lee
Nov 7, 2012·Journal of the American College of Surgeons·Robert CimaUNKNOWN Colorectal Surgical Site Infection Reduction Team
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
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Aug 19, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Seungwon LeeCatherine Liu
May 15, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Azah A AlthumairiJonathan E Efron
Jul 8, 2016·Diseases of the Colon and Rectum·Jashvant PoeranMadhu Mazumdar
Nov 7, 2016·The Lancet Infectious Diseases·Benedetta AllegranziUNKNOWN WHO Guidelines Development Group

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