Surgical Site Infections in Patients With Type 3 Open Fractures: Comparing Antibiotic Prophylaxis With Cefazolin Plus Gentamicin Versus Piperacillin/Tazobactam

Journal of Orthopaedic Trauma
Jenessa RedfernCraig S Bartlett

Abstract

The purpose of this study was to compare rates of surgical site infection (SSI) in patients with type 3 open fractures who had received cefazolin plus gentamicin versus piperacillin/tazobactam for antibiotic prophylaxis. Retrospective cohort study. Level 1 trauma center. Seven hundred sixty-six patients admitted between January 1, 2004, and December 31, 2012, with open fractures were identified using the National Trauma Data Bank by searching International Classification of Diseases, Ninth Revision (ICD-9) codes. Electronic medical record review revealed 134 patients with type 3 open fractures, of which 72 were included in the final analysis. Administration of cefazolin plus gentamicin or piperacillin/tazobactam for type 3 open fracture antibiotic prophylaxis. SSI, nonunion, death, and rehospitalization rates at 1 year. Surgical site infection at 1 year occurred in 12 of 37 patients (32.4%) in the cefazolin plus gentamicin group and 11 of 35 patients (31.4%) in the piperacillin/tazobactam group (P = 1.000). Nonunion, death, and rehospitalization rates at 1 year were similar between the 2 groups. Although there was no statistically significant difference in SSI at 30 days between groups, the rate was higher in the cefazolin plus...Continue Reading

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Citations

Mar 2, 2017·Macromolecular Bioscience·Michael P BevilacquaTimothy J Deming
Mar 16, 2017·Infectious Disease Clinics of North America·Charalampos G Zalavras
Sep 25, 2017·Journal of Orthopaedic Trauma·Paul Toogood, Theodore Miclau
Apr 25, 2018·JBJS Reviews·Erin A MillerStephen A Kennedy
Apr 11, 2018·Journal of Orthopaedic Trauma·Catherine R OlingerJohn C Weinlein
Mar 22, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Reza OmidGeoffrey S Marecek
Dec 19, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Matthew R GarnerHenry Boateng
Apr 21, 2020·The Journal of Bone and Joint Surgery. American Volume·Thomas L HandBoris A Zelle
Jul 20, 2020·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Taku UkaiMasahiko Watanabe
Jan 8, 2021·The Journal of Bone and Joint Surgery. American Volume·Carol A LinUNKNOWN PREP-IT Investigators
Mar 30, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Alexios Dimitrios IliadisNima Heidari
Apr 27, 2021·Journal of Clinical Orthopaedics and Trauma·Yahya IbrahimKashif Akhtar
Mar 23, 2020·OTA International : the Open Access Journal of Orthopaedic Trauma·Daniel Z You, Prism S Schneider
Jul 20, 2021·The Journal of Surgical Research·Amanda MenerRoberto Hernandez-Irizarry
Aug 21, 2021·Journal of Orthopaedic Trauma·Henry C Sagi, Michael J Patzakis
Oct 17, 2020·Surgical Infections·Thompson McMurtrieClay Spitler

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