PMID: 11902320Mar 21, 2002Paper

Surgical strategy and outcomes for epileptic patients with focal cortical dysplasia or dysembryoplastic neuroepithelial tumor

Epilepsia
S KameyamaH Takahashi

Abstract

The purpose of this study was to clarify and compare the influence of surgical strategy on relief from seizures in patients with focal cortical dysplasia (FCD) and those with dysembryoplastic neuroepithelial tumor (DNT). Six patients with FCD and five patients with DNT, all of whom underwent surgical resection for medically intractable epilepsy, were compared in terms of presurgical seizure types and frequency, location of lesions, magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) with 99mTc-ECD, scalp electroencephalogram (EEG), and long-term video-EEG recording. Prolonged subdural recordings and intraoperative electrocorticograms (ECoG) were analyzed. The influences of surgical strategies on seizure outcomes were retrospectively analyzed. In all the FCD patients, ictal SPECT revealed hyperperfusion in the regions where MRI showed FCD. Interictal epileptiform activity and ictal seizure onset on ECoG performed with subdural electrodes were localized on the FCD itself. In contrast, the tumors of all the DNT patients were depicted as hypoperfuse areas on interictal SPECT scans. Ictal SPECT in one DNT patient showed hyperperfusion in the area enclosing the tumor. Interictal spiking in all DNT pat...Continue Reading

Citations

Jul 13, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ricardo Silva CentenoSergio Cavalheiro
Apr 22, 2008·Neuro-Chirurgie·F Chassoux
Aug 12, 2003·Revue neurologique·C Daumas-Duport, P Varlet
Apr 6, 2004·Pediatric Clinics of North America·Cormac O Maher, Corey Raffel
Apr 27, 2007·Neurosurgery·Jorge A González-MartínezWilliam E Bingaman

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