PMID: 9448613Feb 4, 1998Paper

Surgical strategy for the management of hilar bile duct cancer

The British Journal of Surgery
Y ParcR Parc

Abstract

Since the first attempts at resection of Klatskin tumours, an increasingly aggressive surgical treatment has been proposed. Results obtained after examination of the specimen have shown that a significant proportion of resections were palliative. Curative resection appears to be difficult to perform selectively. This retrospective study evaluates the results of a surgically-oriented management of hilar bile duct cancers. Thirty-nine patients were operated on in the period 1982-1994. Eighteen resections were carried out, requiring liver resection in 13 cases. Pathology of the specimen showed that the resection had been curative in 14 cases. The remaining 21 patients had surgical palliation, i.e. bypass and/or stenting. In the resection group, there was no death but four patients suffered severe complications. The 1- and 5-year survival rates were 67 and 47 per cent respectively, with a median survival of 26 months. In the palliation group, the mortality rate was 14 per cent and median survival was 7 months. In the absence of evident contraindications, surgical exploration is worthwhile as it allows detection of the cases where curative resection is possible. Curative resection often requires a major hepatectomy, but mortality an...Continue Reading

References

Nov 17, 1979·Lancet·J S DooleyS Sherlock
Jan 1, 1992·Annals of Surgery·H BismuthT Diamond
Jun 1, 1991·The British Journal of Surgery·Y NimuraS Shionoya
Feb 1, 1987·Annals of Surgery·E C LaiJ J Roslyn
May 1, 1986·Seminars in Liver Disease·J BernuauJ P Benhamou
Sep 1, 1973·Annals of Surgery·W P LongmireJ Hiatt
Oct 1, 1983·Archives of Surgery·T TsuzukiH Yoshii
Mar 1, 1995·Journal of Clinical Ultrasound : JCU·C E NeumaierE Silvestri
Aug 1, 1994·The British Journal of Surgery·E C LaiJ Wong
Jan 1, 1994·The British Journal of Surgery·K TsukadaT Muto
Jan 1, 1993·Annals of Surgery·H U BaerL H Blumgart

❮ Previous
Next ❯

Citations

Dec 29, 2000·Seminars in Surgical Oncology·W R Jarnagin
Nov 15, 2002·Cancer Detection and Prevention·Hassan Abou-RebyehPeter Neuhaus
Sep 27, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W T KnoefelJ R Izbicki
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J FiguerasE Jaurrieta
Oct 17, 2001·Surgery·S R JohnsonD W Hanto
Aug 6, 2008·World Journal of Gastroenterology : WJG·Wei-Jun FanChang-Yu Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.