Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery

Anesthesia and Analgesia
Takashi KawasakiAkio Shigematsu

Abstract

It is generally accepted that major surgery is associated with severe alterations of the host-defense mechanisms. We investigated the effect of surgical stress on the immune system. Specifically, we studied the relationship between perioperative lipopolysaccharide (LPS) hyporesponsiveness and monocyte human leukocyte antigen-DR (HLA-DR) and CD14 expression during the perioperative period in 20 patients who underwent partial gastrectomy. This study demonstrated that surgical stress rapidly depressed monocyte mCD14 and HLA-DR expression in comparison with preanesthesia levels. Monocyte mCD14 expression recovered to preoperative levels on the first postoperative day, and monocyte HLA-DR expression recovered by the seventh postoperative day. Consistent with our previous study, LPS-induced tumor necrosis factor (TNF)-alpha production ex vivo was significantly suppressed from the beginning of the operation. On the contrary, the plasma interleukin-10 concentration started to increase after the surgical incision was made. LPS hyporesponsiveness was least at the end of the operation and returned to preoperative levels on the first postoperative day. In conclusion, the present study demonstrated that LPS responsiveness, plasma interleuki...Continue Reading

References

Dec 1, 1992·The Journal of Experimental Medicine·E A FreyS D Wright
Jan 1, 1992·Research in Immunology·C SchüttC Krüger
Jun 11, 1991·American Journal of Surgery·W G CheadleH C Polk
Feb 1, 1990·The British Journal of Surgery·M J HershmanH C Polk
Dec 1, 1986·European Journal of Immunology·V BazilI Hilgert
Sep 9, 1982·Nature·D S SnyderE R Unanue
Oct 1, 1995·The Journal of Trauma·R ZellwegerI H Chaudry
Mar 1, 1995·The Journal of Infectious Diseases·R LandmannT Calandra
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E FerreroS M Goyert
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PuginP S Tobias
Mar 1, 1993·Immunology Today·H W Ziegler-Heitbrock, R J Ulevitch
Apr 1, 1997·Archives of Surgery·A KlavaP J Guillou
May 29, 1998·Journal of Clinical Anesthesia·M KatoY Hashimoto
Sep 29, 2000·Critical Care Medicine·M OgataA Shigematsu

❮ Previous
Next ❯

Citations

Sep 24, 2005·International Archives of Allergy and Immunology·Hans Jurgen HoffmannRonald Dahl
May 27, 2006·American Journal of Respiratory and Critical Care Medicine·Claudia SpiesHans-Dieter Volk
Feb 20, 2009·Anesthesia and Analgesia·Alexandra LauClaudia Spies
Aug 14, 2010·Anesthesia and Analgesia·Tetsuya TakahashiTomiei Kazama
Mar 15, 2005·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J A HoffmanM S Woo
Jan 6, 2009·Journal of the American Veterinary Medical Association·Abel B EkiriJorge A Hernandez
Mar 31, 2012·Journal of Leukocyte Biology·Vanesa Gómez-PiñaEduardo López-Collazo
Sep 8, 2011·Surgical Endoscopy·Konstantinos E TsimogiannisGeorge Basdanis
Apr 24, 2013·The Journal of Trauma and Acute Care Surgery·Takashi KawasakiTakeyoshi Sata
Dec 7, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Matthew Morris, Liwu Li
Oct 19, 2013·Clinical and Experimental Immunology·E Guillén-GómezM M Díaz-Encarnación
Sep 10, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shougen CaoYu Li
Mar 23, 2011·Acta Anaesthesiologica Scandinavica·V ChalhoubD Benhamou
Oct 5, 2006·Current Opinion in Anaesthesiology·I Kelbel, M Weiss
Jan 27, 2006·World Journal of Gastroenterology : WJG·Nestor González-RoldánArmando Isibasi
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhra K BiswasVinay Tergaonkar
Dec 8, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·D BastianO Reikerås
Nov 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Katalin KarikóFrank A Welsh
Jul 5, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Daniel BastianOlav Reikerås
Mar 4, 2020·Intensive Care Medicine·Didier Payen
Mar 26, 2004·Surgery·Hirofumi IkushimaHikaru Matsuda
Apr 6, 2005·Transplantation Proceedings·J StanisławskaW L Olszewski
Jul 27, 2002·Critical Care Clinics·Thomas H Kalb, Scott Lorin
Aug 13, 2015·Intensive Care Medicine Experimental·David J CainGareth L Ackland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved