Surgical systems biology and personalized longitudinal phenotyping in critical care

Personalized Medicine
Laura J MuirheadJeremy K Nicholson

Abstract

Systems-wide molecular analysis of the metabolic, inflammatory and immune response to surgical trauma has yet to be translated into the operating room. Surgical patients are exposed to a large number of heterogeneous environmental insults that cannot only be quantified by genome-orientated 'omics platforms. Furthermore, surgery demands rapid or near real-time analysis. Systems-level metabolic phenotyping provides a novel 'global' perspective of an organism's metabolic response to surgical injury and, therefore, serves as an ideal platform for the development of personalized therapies in surgery. This article reviews current personalized approaches to healthcare in surgery and explores future directions for personalized surgical biomarker discovery and therapeutics. In particular, this article discusses our vision of 'personalized metabolic phenotyping' in surgery, and outlines next-generation technologies that will make this approach a reality.

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Citations

Apr 10, 2017·Breast Cancer Research and Treatment·Xiaochen ZhangKathryn H Schmitz
Oct 3, 2020·Nutrition & Metabolism·Elaine HillesheimLorraine Brennan
May 1, 2016·BMC Bioinformatics·Krithika BhuvaneshwarSubha Madhavan
Jan 1, 2013·Metabolites·Richard D Beger
Nov 10, 2013·Analytical Chemistry·Benjamin J BlaiseBernard Allaouchiche

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Methods Mentioned

BETA
nuclear magnetic resonance
nucleic acid amplification
genotyping
biopsy
pharmacotherapy
1
H
gastric bypass
gastric
dissection

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