Surgical techniques for Bone Biopsy in Diabetic Foot Infection, and association between results and treatment duration

Journal of Bone and Joint Infection
Senneville EricRobineau Olivier

Abstract

Surgery is an important part of the management of patients diagnosed with DFO. It consists in some selected patients, to remove all or part of the infected bone(s) or even to amputate all or part of the foot. Despite the use of sophisticated imaging techniques, it is however difficult to remove all the infected tissue while respecting the principles of an economical surgery. Bone biopsy performed at the margins of the resection permits to identify residual osteomyelitis and to adjust the post-surgical antibiotic treatment. Some recent studies have reported the way to perform bone margin biopsies and have assessed the impact of the bone results on the patient's outcome. However, the real impact of a residual osteomyelitis on the risk of recurrent DFO is still debated and questions regarding the interpretation of the results remain to be solved. Similarly, the consequences in terms of choice and duration of the antimicrobial treatment to use in case of positive bone margin are not clearly established.

References

Mar 9, 2010·The International Journal of Lower Extremity Wounds·Javier Aragón-Sánchez
Jan 6, 2011·FEMS Immunology and Medical Microbiology·John William CostertonPatrick DeMeo
Jan 22, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Richard D WeinerPeter Accetta
Mar 1, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Todd J KowalskiWilliam A Agger
Dec 14, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J Aragón-SánchezM J Hernández-Herrero
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky Infectious Diseases Society of America
Jul 24, 2012·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Said AtwayDarren M Woodruff
Jul 25, 2012·Journal of the American Podiatric Medical Association·Alison M BeielerRobert W Belknap
Nov 20, 2012·Orthopaedics & Traumatology, Surgery & Research : OTSR·D VaznaisieneE Senneville
Apr 23, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·R J Molines-BarrosoF J Álvaro-Afonso
Oct 17, 2013·Diabetes Care·José Luis Lázaro-MartínezEsther García-Morales
Feb 5, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Miki FujiiK Yokono
Sep 2, 2016·The International Journal of Lower Extremity Wounds·Neal R BarshesBarbara W Trautner
Apr 14, 2017·Expert Opinion on Pharmacotherapy·Eric Senneville, Olivier Robineau
Oct 4, 2017·Future Microbiology·Jean-Philippe Lavigne, Albert Sotto
May 23, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K JohaniM Malone
Sep 5, 2018·The Journal of Bone and Joint Surgery. American Volume·B MijuskovicT Wolff
Dec 28, 2018·International Wound Journal·Aroa Tardáguila-GarcíaJosé L Lázaro-Martínez
Jul 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Matthew MaloneThomas T Bjarnsholt
Oct 30, 2019·Open Forum Infectious Diseases·Matthew J JohnsonMary T Bessesen
Mar 17, 2020·Diabetes/metabolism Research and Reviews·Benjamin A LipskyUNKNOWN International Working Group on the Diabetic Foot (IWGDF)

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Citations

May 1, 2021·Medicina·Benjamin A Lipsky, İlker Uçkay
Nov 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karim GarianiLker Uçkay
Jul 30, 2021·Expert Opinion on Pharmacotherapy·Raju AhluwaliaNicola Maffulli
Aug 21, 2021·Computational and Mathematical Methods in Medicine·Merab ShalamberidzeMalvina Tatvidze

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Methods Mentioned

BETA
biopsy
surgical resection
amputations
amputation
biopsies
scanning electron microscopy

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