Surgical Techniques for Knee Cartilage Repair: An Updated Large-Scale Systematic Review and Network Meta-analysis of Randomized Controlled Trials

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Radoslav Zamborsky, Lubos Danisovic

Abstract

The aim of this study was to investigate the most appropriate surgical interventions for patients with knee articular cartilage defects from the level I randomized clinical trials. We searched five databases for level I randomized clinical trials. Treatments were compared if reported in more than one study using network meta-analysis to boost the number of included studies per comparison. We studied 21 articles that included 891 patients. Traumatic lesion was the most common cause in the included patients. There were significantly higher failure rates in the microfracture (MF) group compared to autologous chondrocyte implantation (ACI) group at 10-year follow-up. Moreover, osteochondral autograft transplantation (OAT) showed significantly more excellent or good results at > 3-year follow-up compared to MF, whereas MF showed significantly more poor results versus ACI and matrix-induced autologous chondrocyte implantation (MACI). Furthermore, OAT showed significantly more poor results than MACI at 1-year follow-up. Similarly, patients who underwent OAT had higher return-to-activity rates than those with MF. It is noteworthy that the Knee injury and Osteoarthritis Outcome Score was higher in patients who underwent characterized ch...Continue Reading

Citations

Jun 26, 2020·The Journal of Knee Surgery·Anna J SchreinerJames L Cook
Feb 5, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Brian J ColeUNKNOWN BC (BioCartilage) Study Group
Feb 4, 2021·Arthroscopy Techniques·Stefan SchneiderGian M Salzmann
Feb 5, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Fabian BlankeThomas Tischer
Feb 16, 2021·Current Reviews in Musculoskeletal Medicine·Matthew HowellChristopher W Gee
Apr 13, 2021·Der Orthopäde·Matthias J FeuchtJulian Mehl
Apr 27, 2021·Revista española de cirugía ortopédica y traumatología·J VillalbaJ Sánchez
Jun 30, 2021·Journal of ISAKOS·Louis KluyskensDaniel B F Saris
Aug 23, 2021·Revista española de cirugía ortopédica y traumatología·J VillalbaJ Sánchez
Oct 10, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Katherine WangRune B Jakobsen

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