Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years.

Journal of Neuro-oncology
Xiaodong NiuQing Mao

Abstract

Given the rarity in the population with adult thalamic gliomas (ATGs), comprehensive characteristics, treatments and survival outcome are not well characterized. This study was conducted to investigate the comprehensive characteristic and treatment of ATGs and identify the prognostic factors associated with overall survival (OS). A retrospective analysis of newly diagnosed ATGs who underwent surgical resection consecutively was conducted. Survival analysis of OS was performed by Kaplan-Meier analysis. Cox proportional hazard model was used to investigate the possible prognostic factors associated with OS. A total of 102 patients with ATG were enrolled in this study. The median age was 41 years (range 18-68 years). There were 56 (54.9%) males. Sixty-two patients (60.8%) had glioblastoma (GBM). Among these patients, 46 patients (45.1%) had GTR/NTR, 50 patients (49.0%) had STR and 6 patients (5.9%) had PR. Postoperatively, 71.6% of these patients received adjuvant therapy. The median OS was 13.6 months (range 1 week-75 months). COX regression analysis revealed that ATG patients with longer duration of symptoms (p = 0.024), better pre-KPS (p = 0.045), maximal resection (p = 0.013), or lower tumor grade (p = 0.002) had longer OS, an...Continue Reading

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Citations

Feb 2, 2021·Journal of Molecular Neuroscience : MN·Tianwei WangQing Mao
Apr 18, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xingwang ZhouYanhui Liu
Apr 30, 2021·Brain Tumor Research and Treatment·Hong In YoonUNKNOWN KSNO Guideline Working Group

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