Surgical Treatment of Genital Manifestations of Lymphatic Filariasis: A Systematic Review

World Journal of Surgery
Kah Heng Alexander LimPatricia Graves

Abstract

Genital manifestations of lymphatic filariasis (genital LF) are a significant cause of disfigurement and disability in the developing world. Surgery is the standard treatment; however, definitive publications are lacking and best practice remains unclear. An exhaustive search strategy using keyword and subject headings was applied to Medline, EMBASE, Web of Science, CINAHL, and Scopus. Additionally citation lists, Google and Google Scholar, archives of relevant journals and websites were searched systematically. Studies with data on one or more human patient(s) who underwent surgery for genital LF were included. Articles were screened and data extracted by the first author with data verification by the second author. Fifty-seven studies were included: 18 series of ablative surgery, four series of non-ablative surgery and 35 case reports. Poor study quality, heterogeneous case definitions, lack of severity grading and limited follow-up precluded meta-analysis. Two series of simple hydrocelectomies performed in resource-limited settings reported early complication rates of 3.0-3.5 % using eversion and 5-7 % using excision, with recurrence of 7 % and 3-5 %, respectively. Complications were minimal for single-surgeon series and gre...Continue Reading

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Citations

Jan 9, 2019·The British Journal of Surgery·L RoaJ G Meara
Oct 3, 2018·Tropical Medicine and Infectious Disease·Catherine A GordonDonald P McManus
Jun 5, 2021·Annals of Saudi Medicine·Alessia FassariEnrico Fiori
Oct 26, 2021·PLoS Neglected Tropical Diseases·Andualem Deneke BeyeneScott McPherson

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