Surgical treatment of Graves' disease: subtotal or total thyroidectomy?

Surgery
P MiccoliA Pinchera

Abstract

The extent of thyroidectomy in Graves' disease is still controversial. We compared the outcome of two groups of patients with Graves' disease who underwent total and subtotal thyroidectomy, respectively. One hundred forty patients were treated by subtotal (ST, n = 80) or total thyroidectomy (TT, n = 60) between 1988 and 1994 for a large goiter or recurrence of hyperthyroidism after antithyroid drugs. Surgical complications, relapse of hyperthyroidism, and serum levels of antibodies were evaluated. Thyroid-stimulating hormone receptor and thyroperoxidase antibodies significantly decreased in 44 of 60 and in 27 of 60, respectively, of TT patients and in 65 of 80 and 8 of 80, respectively, of ST patients. Thyroid-stimulating hormone antibody levels increased in three ST patients who had relapse of hyperthyroidism and in no TT patients; thyroperoxidase antibodies increased in nine ST patients (four with relapse of hyperthyroidism) and in no TT patients. Vocal cord palsy occurred in two ST (2.5%) and in 1 TT (1.7%) patients; hypoparathyroidism occurred in three ST (3.8%) and in two (3.3%) TT patients. Total thyroidectomy does not present more complications with respect to subtotal thyroidectomy, but it avoids the worsening of thyroi...Continue Reading

References

Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·C MarcocciA Pinchera
Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·L WartofskyM Izumi
May 1, 1990·World Journal of Surgery·A FrillingH D Röher
Nov 1, 1987·The British Journal of Surgery·D J Reid
Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J M McKenzie, M Zakarija
Sep 1, 1969·American Journal of Surgery·B Catz, S L Perzik
Jul 1, 1983·The British Journal of Surgery·D D SugrueE O'Malley
Feb 1, 1981·The British Journal of Surgery·S NoguchiA Noguchi
Nov 1, 1981·American Journal of Surgery·M B FarnellL H Wolff
Jul 1, 1982·World Journal of Surgery·R A WahlH D Röher
Feb 1, 1995·The Journal of Clinical Endocrinology and Metabolism·A PincheraC Marcocci

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Citations

May 1, 2012·Pediatric Surgery International·Elena PeroniGiovanna Weber
Jun 27, 2007·Langenbeck's Archives of Surgery·Jérémie H LefevreFabrice Menegaux
Jun 30, 2000·Endocrinology and Metabolism Clinics of North America·O Alsanea, O H Clark
Aug 10, 2000·The British Journal of Surgery·J L KraimpsJ Barbier
Dec 23, 1998·Clinical Endocrinology·N J Leech, C M Dayan
Mar 16, 2002·Clinical Endocrinology·A BelfioreS Filetti
May 25, 2002·ANZ Journal of Surgery·Michael S BarakateLeigh W Delbridge
Apr 6, 2001·Thyroid : Official Journal of the American Thyroid Association·P Werga-KjellmanG Wallin
Apr 16, 2002·Thyroid : Official Journal of the American Thyroid Association·Hideo Kurihara
Sep 11, 2003·Thyroid : Official Journal of the American Thyroid Association·Mariacarla MoletiFrancesco Vermiglio
Jan 26, 2000·Thyroid : Official Journal of the American Thyroid Association·S Basaria, D S Cooper
Apr 22, 1999·Thyroid : Official Journal of the American Thyroid Association·Q Y Duh
Nov 11, 2005·Thyroid : Official Journal of the American Thyroid Association·J JärhultUNKNOWN TEO Study Group
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Geeta LalOrlo H Clark
Mar 27, 2012·TheScientificWorldJournal·E J LimonardE J Nieveen van Dijkum
Jun 5, 1998·Archives of Disease in Childhood·T D CheethamE P Wraight
Dec 1, 2009·International Journal of Pediatric Endocrinology·Scott A Rivkees, Donald R Mattison
Apr 20, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·Z Kraiem, R S Newfield
Nov 30, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Scott A Rivkees
Feb 9, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Leilei Yuan, Jigang Yang
Jun 8, 2004·Acta chirurgica Iugoslavica·M IgnjatovićP Romić
Sep 18, 2001·Lancet·C M Dayan
Oct 10, 1998·Journal of Endocrinological Investigation·C MarcocciA Pinchera
Apr 23, 2011·Thyroid : Official Journal of the American Thyroid Association·Rebecca S Bahn ChairUNKNOWN American Association of Clinical Endocrinologists
Dec 26, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Antoine DigonnetGuy Andry
Mar 11, 2008·World Journal of Surgery·Peter StålbergPer Hellman
Dec 25, 2009·World Journal of Surgery·Scott M Wilhelm, Christopher R McHenry
Jul 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Kiminori SuginoKunihiko Ito
Dec 3, 2015·International Journal of Surgery·Joy U L StaniforthGuy D Eslick
Jul 29, 2008·Asian Journal of Surgery·Ahmet NartCenk Simsek
Apr 6, 2011·Journal of the American College of Surgeons·David V Feliciano, John D Lyons
Oct 24, 2009·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·A J Lowery, M J Kerin
Aug 13, 2009·Head & Neck·David J TerrisMelanie W Seybt
Jan 29, 1999·Chirurgie; mémoires de l'Académie de chirurgie·R Daou
Jan 22, 2008·American Journal of Surgery·Roy Phitayakorn, Christopher R McHenry
Feb 24, 2006·The Korean Journal of Internal Medicine·Yoon-Young ChoHyun Dae Yoon
Mar 6, 2015·Journal of Endocrinological Investigation·F MenconiM Marinò
Nov 15, 2005·Endocrine Journal·Takafumi MajimaKazuwa Nakao

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