Surgical treatment of hepatic metastases from gastric cancer

Updates in Surgery
Silvia MinistriniGuido Alberto Massimo Tiberio

Abstract

The purpose of the study was to investigate the clinical factors influencing the prognosis of patients submitted to hepatectomy for metastases from gastric cancer and their clinical role. We conducted a retrospective multicentre review. We evaluated how survival from surgery was influenced by patient-related, tumour-related and treatment-related prognostic factors. We analysed data on 144 patients submitted to hepatectomy for metastases from gastric cancer, in the synchronous and metachronous setting. In 117 cases, an R0 resection was achieved, while in 27 an R + hepatic resection was performed. Chemotherapy was administered to 55 patients. Surgical mortality was 2.1% and morbidity 21.5%. One-, 3-, and 5-year OS rates after surgery were 49.9, 19.4 and 11.6%, respectively, with a median OS of 12.0 months. T4 gastric cancer, H3 hepatic involvement, non-curative resection, recurrence after surgery, and abstention from chemotherapy were associated with a worse prognosis. Factor T and H displayed a clear (p < 0.001) cumulative effect. Our data show that R0 resection must be pursued whenever possible. The treatment of T4 gastric cancer with hepatic bilateral and diffuse metastasis (H3) should be considered carefully or it should be p...Continue Reading

References

Aug 1, 1994·The British Journal of Surgery·T OchiaiK Maruyama
May 30, 2001·American Journal of Surgery·S AmbiruN Nakajima
Dec 26, 2001·Annals of Surgery·Keiichi OkanoHajime Maeta
Nov 24, 2006·Annals of Surgery·René AdamDenis Castaing
Jan 16, 2007·Journal of Surgical Oncology·Yoshihiro SakamotoMitsuru Sasako
Feb 29, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S H CheonH C Chung
Mar 11, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A ThelenP Neuhaus
Jan 28, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G A M TiberioS M Giulini
Mar 23, 2010·Hepatology International·Hironori TsujimotoKazuo Hase
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Feb 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Mattia GaranciniFabrizio Romano
Feb 23, 2012·World Journal of Surgery·Claus W SchildbergA Perrakis
Sep 6, 2014·Annals of Surgical Oncology·Guido Alberto Massimo TiberioGiovanni de Manzoni
Jul 4, 2015·World Journal of Gastroenterology : WJG·Audrey H ChoiJoseph Chao
Aug 12, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Eiji OkiUNKNOWN Kyushu Study Group of Clinical Cancer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Guido Alberto Massimo TiberioItalian Research Group for Gastric Cancer
Gan to kagaku ryoho. Cancer & chemotherapy
Naoki MimuraShigehiro Shiozaki
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Chen LiYan Zheng Lin
© 2022 Meta ULC. All rights reserved