Surgical treatment of hepatocellular carcinoma in North America: can hepatic resection still be justified?

Journal of the American College of Surgeons
William C ChapmanWilliam Jarnagin

Abstract

The incidence of hepatocellular cancer (HCC) is increasing dramatically worldwide. Optimal management remains undefined, especially for well-compensated cirrhosis and HCC. This retrospective analysis included 5 US liver cancer centers. Patients with surgically treated HCC between 1990 and 2011 were analyzed; demographics, tumor characteristics, and survival rates were included. There were 1,765 patients who underwent resection (n = 884, 50.1%) or transplantation (n = 881, 49.9%). Overall, 248 (28.1%) resected patients were transplant eligible (1 tumor <5 cm or 2 to 3 tumors all <3 cm, no major vascular invasion); these were compared with 496 transplant patients, matched based on year of transplantation and tumor status. Overall survivals at 5 and 10 years were significantly improved for transplantation patients (74.3% vs 52.8% and 53.7% vs 21.7% respectively, p < 0.001), with greater differences in disease-free survival (71.8% vs 30.1% at 5 years and 53.4% vs 11.7% at 10 years, p < 0.001). Ninety-seven of the 884 (11%) resected patients were within Milan criteria and had cirrhosis; these were compared with the 496 transplantation patients, with similar results to the overall group. On multivariate analysis, type of surgery was ...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P BraletB Terris
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix, Josep M Llovet
Feb 20, 2003·Journal of Hepatology·Josep M Llovet, Michel Beaugrand
Sep 23, 2003·Annals of Surgery·Charles H ChaRonald P DeMatteo
Feb 3, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Pratima SharmaRussell H Wiesner
Mar 26, 2004·Journal of Cancer Research and Clinical Oncology·Bo-Heng ZhangZhao-You Tang
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jacques Belghiti, Reza Kianmanesh
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Marcelo E FacciutoPatricia A Sheiner
Nov 28, 2009·Transplantation Reviews·Kenneth Washburn
May 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sasan RoayaieVincenzo Mazzaferro
Aug 14, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Mashaal DhirChandrakanth Are
Mar 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Souvik Sarkar, Joseph K Lim
Mar 19, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kheng Choon LimPierce K H Chow

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Citations

Aug 11, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Faiz GaniTimothy M Pawlik
Oct 16, 2016·Clinics in Liver Disease·Alan W HemmingKristin Mekeel
Sep 30, 2016·Journal of Hepatology·Alessandro VitaleTimothy M Pawlik
Dec 28, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Narendra BattulaGeorge E Loss
Dec 8, 2016·Current Opinion in Organ Transplantation·Leigh Anne DagefordeWilliam C Chapman
Mar 7, 2019·Digestive Diseases and Sciences·Trevor W ReichmanNarendra R Battula
Jul 20, 2016·Annals of Surgery·Victor M ZaydfudimDavid M Nagorney
Nov 23, 2016·World Journal of Hepatology·Linda L WongJun-Fang Ji
Nov 23, 2019·Cancer Cell International·Zhiqiao ZhangJianqiang Ding
Dec 7, 2016·Annals of Surgical Oncology·Jian ZhengRonald P DeMatteo
Apr 1, 2020·Cancers·Sirish A KishoreDavid C Madoff
Dec 15, 2020·Journal of the American College of Surgeons·Leigh Anne DagefordeMaria B Majella Doyle
Aug 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Malin S EilardMagnus Rizell
Jun 18, 2021·JHEP Reports : Innovation in Hepatology·Nguyen H TranLewis R Roberts

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