Surgical treatment of hepatocellular carcinoma: evidence-based outcomes.

World Journal of Gastroenterology : WJG
Shintaro Yamazaki, Tadatoshi Takayama

Abstract

Surgeons may be severely criticized from the perspective of evidence-based medicine because the majority of surgical publications appear not to be convincing. In the top nine surgical journals in 1996, half of the 175 publications refer to pilot studies lacking a control group, 18% to animal experiments, and only 5% to randomized controlled trials (RCT). There are five levels of clinical evidence: level 1 (randomized controlled trial), level 2 (prospective concurrent cohort study), level 3 (retrospective historical cohort study), level 4 (pre-post study), and level 5 (case report). Recently, a Japanese evidence-based guideline for the surgical treatment of hepatocellular carcinoma (HCC) was made by a committee (Chairman, Professor Makuuchi and five members). We searched the literature using the Medline Dialog System with four keywords: HCC, surgery, English papers, in the last 20 years. A total of 915 publications were identified systematically reviewed. At the first selection (in which surgery-dominant papers were selected), 478 papers survived. In the second selection (clearly concluded papers), 181 papers survived. In the final selection (clinically significant papers), 100 papers survived. The evidence level of the 100 surv...Continue Reading

References

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Citations

Jun 20, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·P PuneetDarius F Mirza
Aug 31, 2011·Journal of Gastroenterology and Hepatology·Sebastian SchmidtTim F Greten
Dec 1, 2012·World Journal of Gastroenterology : WJG·Alessandro CucchettiAntonio Daniele Pinna
Dec 10, 2014·Revista de gastroenterología de México·María Sarai González HuezoUNKNOWN Grupo Mexicano de Consenso de Carcinoma Hepatocelular
Sep 30, 2016·Japanese Journal of Clinical Oncology·Ze-Xin ZhuYong Zeng
May 10, 2017·Bioscience Trends·Hayato AbeTadatoshi Takayama
Aug 6, 2015·World Journal of Hepatology·Tatsuo KandaOsamu Yokosuka

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