Surgical treatment of high stage endometrial cancer: current perspectives

Updates in Surgery
Salvatore Giovanni VitaleAntonio Biondi

Abstract

Endometrial cancer is now the most common gynecologic malignancy. We investigate on new scientific evidences in endometrial cancer, particularly underlined updates in advanced endometrial cancer. Early stage endometrial cancer is the most frequent presentation; however, advanced endometrial cancer that occurs in 3-13 % of cases has bad prognosis. There are two types of endometrial cancer different in molecular pattern, therapeutic strategy and prognosis. Type I endometrial cancers develop in an environment of unopposed estrogen and often arise out of endometrial hyperplasia, characterized by mutations in the PTEN gene, K-ras, and microsatellite instability inception. Type II cancer is not an estrogen-related cancer, occurs predominantly in postmenopausal women, shows typical mutations in p53 and HER2/neu and has a poor prognosis. Preoperative characterization of the type's disease is an essential step for a right diagnosis and treatment. All patients should undergo to surgical staging, except those who are inoperable, according to FIGO recommendation. Surgical debulking, neoadjuvant chemotherapy and interval debulking can be strategy options.

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Citations

Oct 19, 2016·Journal of Psychosomatic Obstetrics and Gynaecology·Salvatore Giovanni VitaleAntonio Simone Laganà
Oct 19, 2016·Journal of Psychosomatic Obstetrics and Gynaecology·Antonio Simone LaganàSalvatore Giovanni Vitale
May 23, 2017·International Journal of Molecular Sciences·Salvatore Giovanni VitaleDiego Rossetti
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Dec 7, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anne Bjerrum KristensenMartin Rudnicki
Jun 20, 2017·Human Fertility : Journal of the British Fertility Society·Salvatore Giovanni VitaleAntonio Simone Laganà
Aug 3, 2019·Journal of Psychosomatic Obstetrics and Gynaecology·Valentina Lucia La RosaJan Tesarik
Sep 18, 2017·Updates in Surgery·Gaetano ValentiAntonio Simone Laganà
Aug 16, 2017·Updates in Surgery·Antonio Macrì
Dec 14, 2018·Archives of Gynecology and Obstetrics·Salvatore Giovanni VitaleAntonio Simone Laganà
Mar 6, 2017·Updates in Surgery·Zoi AnastasiadiMichail Mitsis
Jan 6, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nicole ConcinCarien L Creutzberg
Oct 27, 2020·Minerva medica·Matteo MorottiStephen Damato
Nov 18, 2020·Minerva medica·Pier C ZorzatoStefano Uccella
Nov 19, 2020·Minerva medica·Vito A CapozziLatif HacioĞlu
Feb 20, 2021·Virchows Archiv : an International Journal of Pathology·Nicole ConcinXavier Matias-Guiu
Mar 14, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicole ConcinCarien L Creutzberg
May 7, 2021·American Journal of Obstetrics and Gynecology·Benjamin B AlbrightRebecca A Previs

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