Surgical treatment of microinvasive cervical cancer: analysis of pathologic features with implications on radicality

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Juliana Yoko YonedaLuiz Carlos Zeferino

Abstract

To evaluate pathologic features with implications on surgical radicality in women treated with radical hysterectomy and pelvic lymphadenectomy for cervical cancer stage IA1 with lymph vascular space invasion (LVSI) and stage IA2 by correlating findings in conization and hysterectomy specimens. Women with cervical cancer stage IA1 with LVSI and stage IA2 diagnosed by loop electrosurgical excisional procedure or cold knife conization were treated with radical hysterectomy and pelvic lymphadenectomy from January 1999 to December 2011 in 2 institutions. Fifty patients were enrolled: 40 with stage IA2 and 10 with stage IA1 with LVSI. Median age was 43 (30-67) years. All patients underwent cervical conization for diagnosis (45 loop electrosurgical excisional procedure, 5 cold knife). Lymph vascular space invasion was detected in 15 patients (30%). Two patients had positive pelvic nodes. No parametrial involvement was detected in the entire cohort. Positive margins were present in 35 patients, and residual disease was detected in 22 patients (44%). Positive margins predicted residual disease at radical hysterectomy (P = 0.02). Medium follow-up time was 51 months. One patient developed a pelvic recurrence, and there were no disease-rel...Continue Reading

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Citations

Jan 27, 2016·Current Treatment Options in Oncology·Federica TomaoFabio Landoni
Sep 1, 2016·Future Oncology·Seiya SatoToru Sugiyama
May 20, 2017·American Journal of Obstetrics and Gynecology·Tommy BuchananWilliam Creasman
Mar 18, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Benjamin MargolisJason D Wright
Sep 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sayaka KawashitaMasahiro Nakashima
Jun 1, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Thomas Ind
Jul 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C MarthUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

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