Surgical Treatment of NEN of Small Bowel: A Retrospective Analysis

World Journal of Surgery
F M WatzkaT J Musholt

Abstract

Neuroendocrine Neoplasms of the small intestine have been noticed more frequently over the past 35 years. They constitute about 25% of all NENs and 29% of all tumors of the small intestine. Due to the predominantly indolent nature and overall good prognosis, the benefit of surgical treatment is still debated. In a retrospective study, data of 83 surgically treated patients with neuroendocrine neoplasms of the small intestine, 48 males and 35 females with a median age of 62 years (range 25-86 years) were analyzed. Patient data were documented in the MaDoc database for neuroendocrine tumors of the University Medical Center of Mainz. IBM SPSS Statistics 20 was used for statistical analysis. Kaplan-Meier survival curves and Log-Rank tests, censoring patients at the time of last follow-up, were used to compare the overall survival depending on potential prognostic factors (stage, grade, surgical treatment). At the time of diagnoses, the most common clinical symptoms were abdominal pain (n = 31, 37.3%), bowel obstruction (n = 11, 13.3%), bowel perforation and peritonitis (n = 3, 3.6%), gastrointestinal bleeding (n = 9, 10.8%), weight loss (n = 11, 13.3%), and carcinoid syndrome (n = 27, 32.5%). 65 patients (78.3%) had lymph node meta...Continue Reading

References

Jan 1, 1991·Digestion·H AhlmanL E Tisell
Feb 1, 1993·American Journal of Surgery·M D BassonI M Modlin
Oct 19, 2000·World Journal of Surgery·U OhrvallG Akerström
Feb 19, 2005·Journal of Surgical Oncology·Göran AkerströmLiliana Osmak
Apr 26, 2005·Annals of Surgery·John G TouziosHenry A Pitt
Jul 14, 2006·Advances in Experimental Medicine and Biology·Florencia G QueDavid M Nagorney
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Göran Akerström, Per Hellman
Aug 4, 2007·Virchows Archiv : an International Journal of Pathology·G RindiB Wiedenmann
Dec 20, 2008·American Journal of Surgery·Christine S LandryRobert C G Martin
May 22, 2009·Endocrine-related Cancer·A AhmedJ K Ramage
Dec 17, 2010·World Journal of Gastrointestinal Endoscopy·Hans ScherüblGünter Klöppel
Jun 17, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·T J Musholt
Oct 11, 2011·World Journal of Surgery·Olov NorlénGöran Åkerström

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Citations

May 24, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elettra MerolaGianfranco Delle Fave
Oct 30, 2016·Journal of Surgical Oncology·Cecilia G EthunShishir K Maithel
Aug 19, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Benjamin M MotzJonathan C Salo
Feb 22, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F Weber, H Dralle
Oct 24, 2018·Endocrine Connections·Myrtille FouchéThomas Rimmelé
May 21, 2020·Nutrients·Jakub PobłockiMałgorzata Szczuko
Jul 23, 2020·World Journal of Surgery·N S RajaretnamUNKNOWN Commonwealth Neuroendocrine Tumor Research Collaborative (CommNETs) Surgical Section
Aug 2, 2020·World Journal of Surgery·Julie HalletUNKNOWN Commonwealth Neuroendocrine Tumours Research Collaborative (CommNETs) Surgical Section
Aug 30, 2020·World Journal of Surgery·Jonathan Koea, UNKNOWN Commonwealth Neuroendocrine Tumour Research Collaborative (CommNETs) Surgical Section
Nov 17, 2017·World Journal of Gastroenterology : WJG·Beilei CaiDavid C Metz
Jan 9, 2021·World Journal of Surgery·Maximilian EversDetlef K Bartsch
Jan 17, 2021·Annals of Surgical Oncology·Catherine G TranJames R Howe
Oct 20, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Frank Weber, Henning Dralle
Jun 11, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jie-Bin XieXiao-Ting Wu

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