Surgical treatment of non-small cell lung cancer with isolated synchronous brain metastases.

Journal of Korean Medical Science
Hoseok IJhingook Kim

Abstract

This study is a retrospective examination of our experiences with patients who underwent treatment of isolated synchronous brain metastases coupled with primary non-small cell lung cancer. From January 1995 to June 2004, 12 patients presented with isolated synchronous brain metastases coupled with primary non-small cell lung cancer. The patient was comprised of 8 men and 4 women. The median age was 52 yr, in a range of 32 to 75 yr. Median follow-up duration was 10.6 months, in a range of 2 to 55.8 months. Recurrence developed in 7 patients, and the median interval from 1st treatment to recurrence was 4.5 months (2.8-6.5 months). The overall 1-yr survival rate was 61.7%. The 1-yr survival rates for pathologic N0 and N1 cases were 75% and 66.7%, respectively. The median survival duration for pathologic N2 was 6.2 months (95% CI, 4.8-7.5 months). The 1-yr survival rate for cases of single brain metastasis was 75%. Based on our current observations, we could speculate that aggressive management of primary non-small cell lung cancer and isolated synchronous brain metastases was beneficial in a selected group of patients, as long as the brain lesions and pulmonary lesions were limited or resectable.

References

Jul 1, 1988·The Annals of Thoracic Surgery·J R HankinsJ S McLaughlin
Oct 1, 1986·The Annals of Thoracic Surgery·D J MagilliganJ I Ausman
Feb 1, 1971·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J HortonK B Olson
Aug 26, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K Kelly, P A Bunn
Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N PenelJ J Lafitte

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Citations

Jan 31, 2012·Medical Oncology·Xiaowen PangHelong Zhang
Mar 10, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Seong-Hyun ParkYeun-Mook Park
Feb 19, 2010·Surgical and Radiologic Anatomy : SRA·Murat AcarServet Tatli
Jan 1, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hye Won LeeDo-Hyun Nam

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Methods Mentioned

BETA
surgical resection
biopsies
dissections

Software Mentioned

SPSS

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