Surgical treatment of obesity in DM1--a case report and a review of the literature

Neuromuscular Disorders : NMD
K HåkanssonChristopher Lindberg

Abstract

In patients with myotonic dystrophy type 1 overweight and obesity are frequent. When present this has further negative effects on the patients' pulmonary and muscle function as well as social participation. Anesthesia in myotonic dystrophy type 1 patients is associated with increased risks, especially in those who are obese. We describe the outcome of the first patient reported who has undergone gastric bypass surgery. The operation went without complications. Within two years after surgery she has lost 56.5 kg corresponding to 44% of her preoperative body weight (128.5 kg). She has lost muscle mass and muscle strength, but has gained somewhat in functional tests including pulmonary function and has no longer any need for nocturnal ventilation. Surgical treatment of obesity may be feasible in selected myotonic dystrophy type 1 patients but further studies are needed to determine appropriate criteria for surgery including body mass index limits and how pre- and post-operative follow-up should best be made.

References

Oct 1, 1978·The Journal of Clinical Investigation·R T MoxleyR Thiel
Feb 1, 1984·Annals of Neurology·R T MoxleyJ W Rowe
May 12, 2000·Archives of Physical Medicine and Rehabilitation·B A PhillipsF L Mastaglia
Aug 15, 2001·Obesity Surgery·J E MitchellB A Gosnell
Aug 10, 2005·Archives of Neurology·Jeffrey J Tramonte, Ted M Burns
Dec 20, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Cynthia GagnonJean Mathieu
Feb 7, 2013·Paediatric Anaesthesia·Francis Veyckemans, Jean-Louis Scholtes
Sep 11, 2013·North American Journal of Medical Sciences·Iswanto Sucandy, Gintaras Antanavicius

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Citations

Jul 19, 2018·Obesity Surgery·Manuel Fortun LandechoVictor Valenti

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