Surgical treatment of peri-implantitis lesions with or without the use of a bone substitute-a randomized clinical trial

Journal of Clinical Periodontology
Stefan RenvertGösta Rutger Persson

Abstract

To assess whether the treatment outcome differed between surgical debridement, with or without a bone substitute. Forty-one adults with three- or four-wall peri-implant bone defects were enrolled in a 1-year RCT. Surgical debridement (control group), or in combination with a bone substitute (Endobon®) (test group) was performed. Radiographic evidence of defect fill (primary outcome) was only significant in the test group (P = 0.004). At year 1, no bleeding on probing (BOP) in the control and test groups were 7/20 (35%) and 10/21 (47.6%), respectively (χ2  = 0.67, P = 0.41). Plaque scores did not differ by study group at baseline (P = 0.31), or at year 1 (P = 0.08). Mid-buccal soft tissue recession changes did not differ by groups (P = 0.76). Successful treatment outcome (defect fill ≥1.0 mm, PPD values at implant ≤5 mm, no BOP, and no suppuration was identified in 1/20 (5.0%) control, and 9/21 (42.9%) test individuals (F = 7, 9, P < 0.01). Number needed to treat analysis identified an absolute risk reduction of 32.8% in benefit of the test procedure. (F = 7, 9, P < 0.01). Successful treatment outcome using a bone substitute was more predictable when a composite therapeutic endpoint was considered.

Associated Clinical Trials

Feb 24, 2021·Sıla Çağrı İşler

References

Dec 1, 1987·Oral Microbiology and Immunology·A MombelliN P Land
Jul 19, 2003·Clinical Oral Implants Research·Stavros G KolonidisNoel Claffey
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·K A HingP A Revell
Jun 9, 2007·Journal of Clinical Periodontology·Ann-Marie Roos-JansåkerStefan Renvert
Aug 18, 2009·Clinical Implant Dentistry and Related Research·Philipp SahrmannPatrick R Schmidlin
Apr 9, 2010·Journal of Clinical Periodontology·Frank SchwarzJürgen Becker
Jan 5, 2011·Clinical Oral Implants Research·Ma Piedad Ramírez-FernándezJavier Guardia
Sep 10, 2014·Journal of Clinical Periodontology·Ann-Marie Roos-JansåkerStefan Renvert
Mar 31, 2015·Clinical Oral Implants Research·Yvonne C M de WaalArie Jan van Winkelhoff
Sep 13, 2015·Journal of Clinical Periodontology·Frank SchwarzStefan Renvert
Jun 24, 2016·Clinical Oral Implants Research·Lisa J A Heitz-MayfieldNiklaus P Lang
Jul 17, 2016·Clinical Oral Implants Research·Stefan RenvertRutger G Persson
Sep 7, 2016·The International Journal of Oral & Maxillofacial Implants·Vahid KhoshkamHom-Lay Wang
Nov 12, 2016·Journal of Oral & Maxillofacial Research·Povilas DaugelaNikola Saulacic

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Citations

Oct 3, 2019·Brazilian Oral Research·Arthur Belém Novaes JuniorGabriel Bastos Figueredo
Dec 16, 2018·International Journal of Molecular Sciences·Susanne JungSonja Sielker
Jan 12, 2021·International Journal of Implant Dentistry·Ausra RamanauskaiteKarina Obreja
Apr 4, 2021·Journal of Clinical Medicine·Andrea RoccuzzoGiovanni E Salvi
Mar 17, 2021·Clinical Oral Investigations·Tassiane Panta WagnerAlex Nogueira Haas
Aug 28, 2021·Biology·Lorenzo MordiniUgo Consolo
Oct 14, 2021·Clinical Oral Implants Research·Frank SchwarzLisa Heitz-Mayfield
Oct 16, 2021·Clinical Implant Dentistry and Related Research·Iria González RegueiroJosé María Martínez-González
Feb 2, 2022·Periodontology 2000·Ausra Ramanauskaite, Robert Sader
Feb 2, 2022·Periodontology 2000·Frank SchwarzAusra Ramanauskaite

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