Surgical Treatment of Recurrent Endometrial Cancer: Time for a Paradigm Shift

Annals of Surgical Oncology
Andrea PapadiaFrancesco Raspagliesi

Abstract

Although surgery represents the cornerstone treatment of endometrial cancer at initial diagnosis, scarce data are available in recurrent setting. The purpose of this study was to review the outcome of surgery in these patients. Medical records of all patients undergoing surgery for recurrent endometrial cancer at NCI Milano between January 2003 and January 2014 were reviewed. Survival was determined from the time of surgery for recurrence to last follow-up. Survival was estimated using Kaplan-Meier methods. Differences in survival were analyzed using the log-rank test. The Fisher's exact test was used to compare optimal versus suboptimal cytoreduction against possible predictive factors. Sixty-four patients were identified. Median age was 66 years. Recurrences were multiple in 38 % of the cases. Optimal cytoreduction was achieved in 65.6 %. Median OR time was 165 min, median postoperative hemoglobin drop was 2.4 g/dl, and median length hospital stay was 5.5 days. Eleven patients developed postoperative complications, but only four required surgical management. Estimated 5-year progression-free survival (PFS) was 42 and 19 % in optimally and suboptimally cytoreduced patients, respectively. At multivariate analysis, only residual...Continue Reading

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Citations

Jun 9, 2016·Expert Review of Anticancer Therapy·Valentina ZanfagninAndrea Mariani
Mar 25, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lavinia DomeniciChristina Fotopoulou
Jul 5, 2018·Expert Review of Anticancer Therapy·Elizabeth V Connor, Peter G Rose
Aug 23, 2017·Journal of Cancer Research and Clinical Oncology·Andrea PapadiaMichael D Mueller
Oct 16, 2018·Minerva ginecologica·Andrea PapadiaMichael D Mueller
Dec 4, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Francesco LeggeFrancesco Fanfani
Feb 21, 2019·Minerva ginecologica·Violante Di Donato, Pierluigi Benedetti Panici
Aug 20, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFrancesco Raspagliesi
May 9, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anna GermanovaDavid Cibula
Nov 30, 2019·Archives of Gynecology and Obstetrics·Andrea PapadiaMichael D Mueller
May 18, 2019·International Journal of Clinical Oncology·Ayumi ShikamaToyomi Satoh
Jan 6, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nicole ConcinCarien L Creutzberg
Feb 20, 2021·Virchows Archiv : an International Journal of Pathology·Nicole ConcinXavier Matias-Guiu
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Jun 7, 2021·Gynecologic Oncology·Lea A MoukarzelJennifer J Mueller
Aug 4, 2021·Interactive Cardiovascular and Thoracic Surgery·Marco ChiappettaStefano Margaritora

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