Surgical treatment of temporoparietooccipital cortical dysplasia in infants: report of two cases

Epilepsia
Roy Thomas DanielJean-Guy Villemure

Abstract

Extensive multilobar cortical dysplasia in infants commonly is first seen with catastrophic epilepsy and poses a therapeutic challenge with respect to control of epilepsy, brain development, and psychosocial outcome. Experience with surgical treatment of these lesions is limited, often not very encouraging, and holds a higher operative risk when compared with that in older children and adults. Two infants were evaluated for surgical control of catastrophic epilepsy present since birth, along with a significant psychomotor developmental delay. Magnetic resonance imaging showed multilobar cortical dysplasia (temporoparietooccipital) with a good electroclinical correlation. They were treated with a temporal lobectomy and posterior (parietooccipital) disconnection. Both infants had excellent postoperative recovery and at follow-up (1.5 and 3.5 years) evaluation had total control of seizures with a definite "catch up" in their development, both motor and cognitive. No long-term complications have been detected to date. The incorporation of disconnective techniques in the surgery for extensive multilobar cortical dysplasia in infants has made it possible to achieve excellent seizure results by maximizing the extent of surgical treatm...Continue Reading

References

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Citations

Nov 3, 2011·Journal of Neurosurgery. Pediatrics·Mohammad-Ali JazayeriSean M Lew
Oct 10, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·G TamburriniC Di Rocco
Feb 13, 2016·Journal of Neurosurgery. Pediatrics·Jun T ParkJonathan P Miller
Feb 18, 2012·Brain & Development·Yoshiko IwataniKeiichi Ozono
Mar 1, 2006·Brain & Development·Hoon-Chul KangTae-Sung Ko
Jan 1, 2013·Epilepsy & Behavior Case Reports·Alexey Y StepanenkoAlla B Guekht
Oct 19, 2010·Seizure : the Journal of the British Epilepsy Association·F NovegnoF Guzzetta
Nov 13, 2012·Journal of Child Neurology·Saleem I MalikDavid J Donahue
Dec 9, 2017·Journal of Neurosurgery. Pediatrics·Giulia CossuRoy Thomas Daniel
Aug 31, 2019·Epilepsia·Thilo KalbhennChristian G Bien
Nov 27, 2018·Seizure : the Journal of the British Epilepsy Association·Jonathan DallasRobert P Naftel
Jun 9, 2021·Seizure : the Journal of the British Epilepsy Association·Christopher MarkosianLuke D Tomycz
May 3, 2007·Pediatrics·Tobias LoddenkemperElaine Wyllie

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