Surgical treatment of the primary tumor in stage IV breast cancer

Cirugía española
Juan Jiménez AnulaBasilio Dueñas Rodríguez

Abstract

The aim of the study was to analyze the impact of loco-regional surgery on survival of patients with stage IV breast cancer. Retrospective study that included patients with breast cancer and synchronous metastases. Patients with ECOG above 2 and high-risk patients were excluded. The following variables were evaluated: age, tumor size, nodal involvement, histological type, histological grade, hormone receptor status, HER2 overexpression, number of affected organs, location of metastases and surgical treatment. The impact of surgery and several clinical and pathologic variables on survival was analyzed by Cox regression model. A total of 69 patients, of whom 36 (52.2%) underwent surgery (study group) were included. After a mean follow-up of 34 months, the median survival of the series was 55 months and no significant differences between the study group and the group of patients without surgery (P=0.187) were found. Two factors associated with worse survival were identified: the number of organs with metastases (HR=1.69, IC 95%: 1.05-2.71) and triple negative breast cancer (HR=3.49, IC 95%: 1.39-8.74). Loco-regional surgery, however, was not associated with survival. Loco-regional surgical treatment was not associated with improve...Continue Reading

References

May 17, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elisabetta RapitiChristine Bouchardy
Jun 27, 2008·Breast Cancer Research and Treatment·Andrea C BaffordMehra Golshan
Feb 3, 2009·Annals of Surgical Oncology·E IgnantiadouM Fatouros
Apr 21, 2009·The Journal of Surgical Research·Anna M LeungHarry D Bear
Jun 10, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D Ali, R Le Scodan
Jun 30, 2011·Breast Cancer Research and Treatment·Laura DominiciMehra Golshan
Aug 6, 2011·The Breast : Official Journal of the European Society of Mastology·Jose Alejandro Pérez-FidalgoAna Lluch
Oct 29, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z M RashaanG J Liefers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.