Surgical treatment of ulcerative colitis in the biologic therapy era.

World Journal of Gastroenterology : WJG
Alberto BiondiAlessandro Fichera

Abstract

Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis, biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease. The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven. Furthermore, these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications. Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients. Surgery is traditionally recommended as salvage therapy when medical management fails, and, despite advances in medical therapy, colectomy rates remain unchanged between 20% and 30%. To overcome the reported increase in postoperative complications in patients on biologic therapies, several surgical strategies have been developed to maintain long-term pouch failure rate around 10%, as previously reported. Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this...Continue Reading

References

Jul 8, 1978·British Medical Journal·A G Parks, R J Nicholls
Jul 1, 1992·Diseases of the Colon and Rectum·S D WexnerD G Jagelman
Jul 4, 1992·BMJ : British Medical Journal·A B HawthorneJ E Lennard-Jones
Dec 1, 1991·Scandinavian Journal of Gastroenterology·E LangholzV Binder
Apr 1, 1987·Journal of Clinical Gastroenterology·R CaprilliA Torsoli
Aug 1, 1994·International Journal of Colorectal Disease·S L SchmittD G Jagelman
Mar 1, 1995·Diseases of the Colon and Rectum·B DamgaardP Kirkegaard
Jun 30, 1994·The New England Journal of Medicine·S LichtigerS Hanauer
Nov 1, 1993·Diseases of the Colon and Rectum·J J TjandraJ M Fabre
Oct 1, 1993·Digestive Diseases and Sciences·T H BaronC O Elson
Mar 1, 1996·Scandinavian Journal of Gastroenterology·E LangholzV Binder
Jun 1, 1996·Gut·S P TravisD P Jewell
Sep 18, 1997·Diseases of the Colon and Rectum·M E WilliamsonD Johnston
Feb 19, 1998·The American Journal of Gastroenterology·A MartinR Naccarato
Nov 27, 1998·European Journal of Gastroenterology & Hepatology·S C LindgrenR I Sjödahl
Jun 18, 1999·Gastroenterology Clinics of North America·J M Becker
Jun 1, 2001·Inflammatory Bowel Diseases·B E SandsD K Podolsky
Oct 13, 2001·Diseases of the Colon and Rectum·G M HydeN J Mortensen
Oct 13, 2001·Diseases of the Colon and Rectum·P W MarcelloV W Fazio
Jul 5, 2002·Surgical Endoscopy·R L Bell, N E Seymour
Oct 8, 2003·Annals of Surgery·Victor W FazioConor P Delaney
Oct 18, 2003·International Journal of Colorectal Disease·W E HuetingC J H M van Laarhoven
Jul 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jeffrey P LakeRobert W Beart
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Thomas OchsenkühnBurkhard Göke
Jan 14, 2005·European Journal of Gastroenterology & Hepatology·Simon CampbellDerek Jewell
Feb 5, 2005·Diseases of the Colon and Rectum·Neil H HymanTurner Osler
Feb 16, 2005·Alimentary Pharmacology & Therapeutics·J R F CummingsD P Jewell
Feb 17, 2005·Diseases of the Colon and Rectum·Kutt-Sing WongVictor W Fazio

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Citations

Sep 5, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Liliana Bordeianou, Lillias Maguire
Mar 14, 2013·World Journal of Gastroenterology : WJG·Ya-Jie ZhangLiang Huang
Apr 8, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mahmoud MosliMajid Almadi
Oct 23, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Caitlin W HicksLiliana Bordeianou
Nov 1, 2013·Pediatric Surgery International·Emanuela CeriatiMassimo Rivosecchi
Feb 4, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kajsa EdforsCharlotte Söderman
Jan 24, 2015·Scandinavian Journal of Gastroenterology·János TajtiGyörgy Lázár
Nov 19, 2015·Expert Review of Gastroenterology & Hepatology·Steven Lee-Kong, Ravi Pokala Kiran
Sep 1, 2015·Journal of Digestive Diseases·Rosario FornaroElisa Caratto
Sep 16, 2014·Inflammatory Bowel Diseases·Bikash Devaraj, Andreas M Kaiser
Nov 8, 2014·Diseases of the Colon and Rectum·Cristina B GeltzeilerVassiliki L Tsikitis
Sep 21, 2016·World Journal of Gastrointestinal Surgery·Luigi SofoMaurizio Bossola
Feb 1, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N S FearnheadS R Brown
Sep 25, 2018·Journal of Pediatric Gastroenterology and Nutrition·Jennifer B MitsuyaMohammad El-Baba
Jan 22, 2020·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·E K KarjalainenA H Lepistö
Jul 14, 2018·International Journal of Colorectal Disease·Jörn GröneMario H Mueller
Apr 13, 2019·Gastroenterology Report·Daniel J WongVitaliy Y Poylin
Dec 8, 2020·The American Surgeon·Simon Peter T TiuJeffrey S Barton
Jan 28, 2021·Inflammatory Bowel Diseases·Essi K KarjalainenAnna H Lepistö
Feb 12, 2020·Cellular and Molecular Gastroenterology and Hepatology·Elvira MennilloShujuan Chen
May 12, 2021·World Journal of Emergency Surgery : WJES·Belinda De SimoneFausto Catena
Apr 2, 2020·Inflammatory Intestinal Diseases·Saki YamadaToshifumi Wakai

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