Surgical treatment variation in a prospective, randomized trial of chemoradiotherapy in gastric cancer: the effect of undertreatment

Annals of Surgical Oncology
S A HundahlSouthwest Oncology Group and the Gastric Intergroup

Abstract

Intergroup 0116 (Southwest Oncology Group 9008), a national, multicenter, two-armed, prospective, randomized trial of adjuvant postoperative chemoradiotherapy, has demonstrated significant benefit. We prospectively captured complete surgical information, including the treatment of various lymph node stations, for 553 of the 556 eligible participants in this trial. Before any survival analysis, we coded D level by using the Japanese general rules and used the Maruyama program to estimate the likelihood of disease in undissected regional node stations, defining the sum of these estimates as the Maruyama Index of Unresected Disease (MI). We analyzed survival with Cox multivariate regression. Fifty-four percent of participating patients underwent D0 lymphadenectomy. The median MI was 70 (range, 0-429). In contrast to D level, MI proved to be an independent prognostic factor, even with adjustment for the potentially linked variables of T stage and number of positive nodes. We detected no significant interaction between surgical or pathologic variables and the favorable effect of adjuvant treatment, but the power to detect such interaction was generally low. MI, a measure of unresected regional nodal disease in gastric cancer, proved...Continue Reading

References

Dec 1, 1989·The British Journal of Surgery·J W Fielding
Jul 1, 1995·World Journal of Surgery·K MaruyamaK Okajima
Dec 11, 1997·The British Journal of Surgery·M Sasako
Mar 25, 1999·The New England Journal of Medicine·J J BonenkampUNKNOWN Dutch Gastric Cancer Group
Mar 25, 1999·The New England Journal of Medicine·M F Brennan
Apr 14, 1999·CA: a Cancer Journal for Clinicians·D M ParkinJ Ferlay
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun

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Citations

Apr 4, 2014·World Journal of Gastroenterology : WJG·Wei DengLin Shen
Mar 30, 2011·Updates in Surgery·Marco CatarciGiovanni Battista Grassi
Apr 5, 2014·Annals of Surgical Oncology·Wesley A PapenfussNeal W Wilkinson
Aug 13, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Johan L DikkenCornelis J H van de Velde
Dec 1, 2005·World Journal of Surgery·K C M J PeetersC J H van de Velde
Apr 17, 2007·Annals of Surgery·Peter C EnzingerCharles S Fuchs
Jul 3, 2009·Surgical Endoscopy·Melanie GoldfarbS D Schwaitzberg
Jul 16, 2010·World Journal of Gastroenterology : WJG·Alberto BiondiDomenico D'Ugo
Nov 3, 2011·World Journal of Gastroenterology : WJG·Ibrahim SakcakEnver O Hamamci
May 14, 2005·Critical Reviews in Oncology/hematology·Vincenzo CatalanoEric Van Cutsem
Jan 19, 2011·Japanese Journal of Clinical Oncology·Makoto SakaHitoshi Katai
Apr 21, 2007·Digestive Surgery·M SasakoT Sano
Mar 11, 2004·Current Treatment Options in Gastroenterology·Walter Lawrence
Nov 19, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Javier Escrig Sos, David Martínez Ramos
Jul 11, 2012·International Journal of Surgical Oncology·R A SnyderN B Merchant
Oct 26, 2005·Annals of Surgical Oncology·Nancy N Baxter, Todd M Tuttle
Aug 20, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E P M JansenA Cats
Nov 22, 2011·Surgical Oncology Clinics of North America·Mitsuru Sasako
Nov 22, 2011·Surgical Oncology Clinics of North America·Scott A Hundahl
Nov 22, 2011·Surgical Oncology Clinics of North America·Hisakazu Hoshi
Dec 4, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L MaranoF Roviello
Sep 22, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y PointreauI Barillot
Jul 25, 2009·Lancet·Henk H HartgrinkCornelis J H van de Velde
Feb 24, 2009·Critical Reviews in Oncology/hematology·Vincenzo CatalanoEric Van Cutsem
Sep 2, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C HennequinL Mineur
Sep 2, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Michel
Jun 10, 2008·International Journal of Radiation Oncology, Biology, Physics·Ralf-Dieter HofheinzAndreas Hochhaus
Jun 15, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A MarchetUNKNOWN Italian Research Group for Gastric Cancer Study (GIRCG)
Apr 17, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·W K TsangA T C Chan
Mar 6, 2007·Surgical Oncology Clinics of North America·Harold O DouglassVijay P Khatri
Oct 1, 2004·ANZ Journal of Surgery·G Bruce Mann
Jul 11, 2009·The British Journal of Surgery·J KuligUNKNOWN Polish Gastric Cancer Study Group
Nov 1, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W Scheithauer, E Van Cutsem
Jan 15, 2009·Journal of Surgical Oncology·Natalie G Coburn
Aug 28, 2015·The British Journal of Surgery·W O de SteurC J H van de Velde
Jul 17, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H H HartgrinkUNKNOWN Cooperating Investigators of The Dutch Gastric Cancer Group
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Peter McCulloch
Sep 27, 2006·Current Problems in Surgery·Clancy J ClarkEugene Lin

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