Surgical wound healing in bleeding disorders

Haemophilia : the Official Journal of the World Federation of Hemophilia
E C Rodriguez-Merchan

Abstract

Animal experiments have shown that a number of bleeding disorders may affect wound healing (WH), including haemophilia B, deficiency of factor XIII and abnormalities of fibrinogen. Therefore, normal healing requires adequate haemostatic function for the appropriate time frame (up to 4 weeks in the clean and uncontaminated wound). Many factors may affect WH, including impaired haemostasis, diabetes, poor nutrition, insufficient oxygenation, infection, smoking, alcoholism, old age, stress and obesity. The gold standard for the correct care of surgical wounds in patients with bleeding disorders includes wound dressing and comprehensive standard care (haemostasis, nutritional support, treatment of co-morbidities, offloading, reperfusion therapy and compression). Although complications of surgical wounds healing in patients with bleeding disorders are uncommon, a low level of the deficient factor for an insufficient period of time could cause WH complications such as haematomas, infection, and skin necrosis and dehiscence. Clinical experience and animal experiments appear to indicate that, to get a satisfactory healing of surgical wounds and avoid potential complications of WH, a good level of haemostasis is necessary for 2-3 weeks ...Continue Reading

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Citations

Oct 26, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zafer SalciogluZafer Baslar
Mar 4, 2014·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Judy Kauffman
Mar 26, 2014·Journal of Pediatric Hematology/oncology·Holly Lindsay, Lakshmi V Srivaths
Jan 17, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L Castellanos-CosanoJ J Segura-Egea
Jul 25, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M MonroeU Hedner
Aug 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Kulkarni
Jun 14, 2016·Expert Review of Hematology·Lucia StanciakovaJan Stasko
Oct 19, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Anetta Undas
Aug 3, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Bin FengXisheng Weng
Nov 18, 2016·Frontiers in Physiology·Constantinus PolitisJimoh O Agbaje
Aug 17, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Nathan H VaradyAntonia F Chen
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Aug 19, 2021·Hematology/oncology Clinics of North America·Jori E MayMing Yeong Lim

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