Abstract
Animal experiments have shown that a number of bleeding disorders may affect wound healing (WH), including haemophilia B, deficiency of factor XIII and abnormalities of fibrinogen. Therefore, normal healing requires adequate haemostatic function for the appropriate time frame (up to 4 weeks in the clean and uncontaminated wound). Many factors may affect WH, including impaired haemostasis, diabetes, poor nutrition, insufficient oxygenation, infection, smoking, alcoholism, old age, stress and obesity. The gold standard for the correct care of surgical wounds in patients with bleeding disorders includes wound dressing and comprehensive standard care (haemostasis, nutritional support, treatment of co-morbidities, offloading, reperfusion therapy and compression). Although complications of surgical wounds healing in patients with bleeding disorders are uncommon, a low level of the deficient factor for an insufficient period of time could cause WH complications such as haematomas, infection, and skin necrosis and dehiscence. Clinical experience and animal experiments appear to indicate that, to get a satisfactory healing of surgical wounds and avoid potential complications of WH, a good level of haemostasis is necessary for 2-3 weeks ...Continue Reading
References
Feb 14, 1998·Dermatologic Clinics·C Y Cho, J S Lo
Sep 11, 2003·Clinical Orthopaedics and Related Research·George CiernyJohan J Penninck
Mar 4, 2006·BMJ : British Medical Journal·David J Leaper
Jul 11, 2006·Blood·Maureane HoffmanDougald M Monroe
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·A McDonaldD M Monroe
Dec 7, 2007·Blood·Anna G McDonaldMaureane Hoffman
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·M Hoffman
Jan 15, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L Hsieh, D Nugent
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chandan K Sen
Jan 30, 2010·Thrombosis Research·David H Bevan
Feb 9, 2010·Journal of Dental Research·S Guo, L A Dipietro
Feb 23, 2010·Thrombosis Research·Dougald M MonroeMaureane Hoffman
Jul 9, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·M Hoffman, D M Monroe
Sep 16, 2010·Orthopedics·Richard E Jones
Jun 8, 2011·Journal of Wound Care·S E DowdS B Cox
Aug 23, 2011·Facial Plastic Surgery Clinics of North America·Geoffrey B Pitzer, Krishna G Patel
Citations
Oct 26, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zafer SalciogluZafer Baslar
Mar 4, 2014·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Judy Kauffman
Mar 26, 2014·Journal of Pediatric Hematology/oncology·Holly Lindsay, Lakshmi V Srivaths
Jan 17, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L Castellanos-CosanoJ J Segura-Egea
Jul 25, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M MonroeU Hedner
Aug 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Kulkarni
Mar 31, 2016·Orthopaedic Surgery·Ye LiJi-liang Zhai
Dec 27, 2012·International Journal of Surgery·Jawad AhmadRoy A J Spence
Jun 14, 2016·Expert Review of Hematology·Lucia StanciakovaJan Stasko
Oct 19, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Anetta Undas
Mar 20, 2019·The Kaohsiung Journal of Medical Sciences·Jia-Ruey TsaiChia-Yau Chang
Aug 3, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Bin FengXisheng Weng
Nov 18, 2016·Frontiers in Physiology·Constantinus PolitisJimoh O Agbaje
Feb 23, 2020·Disease Markers·Konstanty SzułdrzyńskiAnetta Undas
Jul 26, 2019·Orphanet Journal of Rare Diseases·Siyu MaQiulan Ding
Jan 10, 2019·Journal of Immunology Research·Mihai BucurEcaterina Ionescu
Apr 19, 2017·International Wound Journal·Hyun Ho HanJong Won Rhie
Aug 17, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Nathan H VaradyAntonia F Chen
Jan 4, 2019·ACS Applied Materials & Interfaces·Ismaeel MuhamedAshley C Brown
Aug 19, 2021·Hematology/oncology Clinics of North America·Jori E MayMing Yeong Lim