SURI and Kir6.1 subunits of K(ATP)-channels are co-localized in retinal glial (Müller) cells

Neuroreport
M J EatonAndreas Reichenbach

Abstract

ATP-sensitive potassium channels (K(ATP)), unlike other inwardly rectifying potassium (Kir) channels, require two structurally diverse subunits to form functional channels: one member of the Kir6 channel family (Kir6.1 or Kir6.2), and one sulfonylurea receptor (SUR) of the ATP-binding cassette superfamily (SURI, SUR2A or SUR2B). We have previously shown that two pore-forming subunits of K(ATP)-channels are differently distributed in frog retina. Kir6.1 is localized in Miller (glial) cells, whereas Kir6.2 is found in neurons. Using immunocytochemistry, the present study reveals that in adult frog retina, SURI is restricted to Müller (glial) cells whereas SUR2A and SUR2B are found in neurons. These data suggest that functional K(ATP) channels in Müller cells may be formed by Kir6.1/SURI, and in neurons by Kir6.2/SUR2A and/or Kir6.2/SUR2B.

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Citations

Apr 13, 2004·Neuroreport·Misty J EatonSerguei N Skatchkov
Mar 17, 2007·Current Eye Research·Andreas BringmannSusann Uhlmann
Mar 28, 2006·Journal of Cellular and Molecular Medicine·Arthur M Butt, Amanpreet Kalsi
Jan 20, 2018·Physiological Reviews·Alexei Verkhratsky, Maiken Nedergaard
Jun 23, 2015·PloS One·Kimberleve Rolón-ReyesLilia Y Kucheryavykh

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