Surprising similarity between mechanisms mediating low (1 Hz)-and high (100 Hz)-induced long-lasting synaptic potentiation in CA1 of the intact hippocampus

Neuroscience
Diala Habib, Hans C Dringenberg

Abstract

It is generally assumed that long lasting synaptic potentiation (long-term potentiation, LTP) and depression (long-term depression, LTD) result from distinct patterns of afferent activity, with high and low frequency activity favouring LTP and LTD, respectively. However, a novel form of N-methyl-d-aspartate (NMDA) receptor-dependent synaptic potentiation in the hippocampal CA1 area in vivo induced by low frequency afferent stimulation has recently been demonstrated. Here, we further characterize the mechanisms mediating this low frequency stimulation (LFS)-induced LTP in area CA1 of intact, urethane-anesthetized preparations. Consistent with previous reports, alternating, low frequency (1 Hz) stimulation of CA1 afferents originating in the contralateral CA3 area and the medial septum resulted in gradually developing, long lasting (>2 h) LTP of field excitatory postsynaptic potentials (fEPSPs) recorded in CA1. Local application of the protein synthesis inhibitor anisomycin in CA1 blocked LFS-induced LTP, as did application of H89, an inhibitor of protein kinase A. Given the apparent overlap in molecular mechanisms mediating LFS-LTP and "classic" high-frequency stimulation (HFS)-induced LTP in CA1, we examined the relation betwee...Continue Reading

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Citations

Apr 9, 2014·Behavioural Pharmacology·Mohammad-Hasan NaseriMohammad Nasehi
Mar 15, 2012·Neurobiology of Learning and Memory·Yasuhiro SaitoHiroko Togashi
Apr 16, 2013·PloS One·Xiaomin ZhangAndreas Draguhn
Dec 17, 2014·PLoS Computational Biology·Sven JahnkeMarc Timme
Feb 22, 2012·Neurobiology of Disease·James D FrostJohn W Swann
May 21, 2015·Reviews in the Neurosciences·Abdul-Karim AbbasLaurence Ris

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