Surrogate MR markers of response to chemo- or radiotherapy in association with co-treatments: a retrospective analysis of multi-modal studies

Contrast Media & Molecular Imaging
Bénédicte F Jordan, Bernard Gallez

Abstract

The study of magnetic resonance (MR) markers over the past decade has provided evidence that the tumor microenvironnement and hemodynamics play a major role in determining tumor response to therapy. The aim of the present work is to predict and monitor the efficacy of co-treatments to radio- and chemotherapy by noninvasive MR imaging. Ten different co-treatments were involved in this retrospective analysis of our previously published data, including NO-mediated co-treatments (insulin and isosorbide dinitrate), anti-inflammatory drugs (hydrocortisone, NS-398), anti-angiogenic agents (thalidomide, SU5416 and ZD6474), a vasoactive agent (xanthinol nicotinate), botulinum toxin and carbogen breathing. Dynamic contrast enhanced (DCE) MRI, intrinsic susceptibility-weighted (BOLD) MRI and electronic paramagnetic resonance (EPR) oximetry all reflect tumor microenvironment hemodynamic variables that are known to influence tumor response. Eight MR-derived parameters (markers) were tested for their ability to predict therapeutic outcome (factor of increase in regrowth delay) in experimental tumor models (TLT and FSaII) after radiation therapy and/or chemotherapy with cyclophosphamide, namely tumor pO₂ and O₂ consumption rate (using EPR oxi...Continue Reading

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Citations

Sep 10, 2013·Seminars in Radiation Oncology·Pierre DanhierPierre Sonveaux
Oct 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bénédicte F JordanBernard Gallez
Nov 5, 2014·Contrast Media & Molecular Imaging·Pierre Danhier, Bernard Gallez
Dec 2, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ly-Binh-An TranBernard Gallez
Jun 12, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Oussama KarroumBénédicte F Jordan
Jul 17, 2016·Radiation Protection Dosimetry·Bernard Gallez
May 31, 2018·PloS One·Tsuicheng D ChiuStrahinja Stojadinovic
Sep 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Florence ColliezBénédicte F Jordan
Jul 19, 2013·Cancer Research·Martyna ElasHoward J Halpern
Jun 3, 2021·International Journal of Molecular Sciences·Olga ShilovaSergey Deyev

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