Surrogate population models for large-scale neural simulations

Neural Computation
Bryan P Tripp

Abstract

Because different parts of the brain have rich interconnections, it is not possible to model small parts realistically in isolation. However, it is also impractical to simulate large neural systems in detail. This article outlines a new approach to multiscale modeling of neural systems that involves constructing efficient surrogate models of populations. Given a population of neuron models with correlated activity and with specific, nonrandom connections, a surrogate model is constructed in order to approximate the aggregate outputs of the population. The surrogate model requires less computation than the neural model, but it has a clear and specific relationship with the neural model. For example, approximate spike rasters for specific neurons can be derived from a simulation of the surrogate model. This article deals specifically with neural engineering framework (NEF) circuits of leaky-integrate-and-fire point neurons. Weighted sums of spikes are modeled by interpolating over latent variables in the population activity, and linear filters operate on gaussian random variables to approximate spike-related fluctuations. It is found that the surrogate models can often closely approximate network behavior with orders-of-magnitude...Continue Reading

References

Aug 1, 1990·Journal of Neurophysiology·T C Yin, J C Chan
Jun 1, 1972·The Journal of General Physiology·B W Knight
Jun 1, 1994·Journal of Computational Neuroscience·E Salinas, L F Abbott
Dec 23, 2000·Science·J B TenenbaumJ C Langford
Jun 29, 2002·Psychological Review·Wolfram Erlhagen, Gregor Schöner
Jul 23, 2002·Nature Neuroscience·Alexei A KoulakovJohn E Lisman
Jun 7, 2003·Network : Computation in Neural Systems·J C AndersonR T Hanlon
May 25, 2004·Nature Neuroscience·Alon PolskyJackie Schiller
Oct 16, 2004·Psychological Review·John R AndersonYulin Qin
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ray Singh, Chris Eliasmith
Sep 5, 2008·PLoS Computational Biology·Gustavo DecoKarl Friston
Nov 20, 2009·Neural Computation·Bryan P Tripp, Chris Eliasmith
May 16, 2012·Frontiers in Computational Neuroscience·Bryan P Tripp, Jeff Orchard
Jun 23, 2012·Nature·Mark M ChurchlandKrishna V Shenoy
Dec 1, 2012·Science·Chris EliasmithDaniel Rasmussen
Jan 17, 2014·Frontiers in Neuroinformatics·Trevor BekolayChris Eliasmith

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