Surveillance MRI for the detection of locally recurrent Ewing sarcoma seems futile

Skeletal Radiology
Ömer KasalakThomas C Kwee

Abstract

To determine the frequency of locally recurrent Ewing sarcoma on surveillance MRI and the outcome of these patients. This retrospective single-center study included all patients with newly diagnosed Ewing sarcoma who underwent surveillance MRI of the primary tumor location after primary treatment between 1997 and 2016. Thirty-two patients underwent a total of 176 local surveillance MRI scans, yielding an average of 5.5 ± 4.4 MRI scans per patient. Follow-up time of surveillance MRI after completion of primary treatment ranged between 1 and 111 months. Surveillance MRI detected five (15.6%) locally recurrent Ewing sarcomas, at 2, 4, 6, 6, and 7 months after completion of primary treatment, of whom three also had simultaneous recurrent (metastatic) disease elsewhere. Two patients had recurrent metastatic disease without any signs of locally recurrent disease on surveillance MRI. All five patients with locally recurrent disease on surveillance MRI died, at 2, 4, 5, 8, and 9 months after local recurrence detection. Patients with locally recurrent disease had a significantly worse overall survival than patients without locally recurrent disease (log-rank test, P < 0.0001). A limited number of patients have locally recurrent Ewing sa...Continue Reading

References

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Citations

Jan 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ryan D MeekBarry G Hansford
Mar 27, 2020·Journal of Surgical Oncology·Samir SabharwalCarol D Morris
Nov 22, 2020·Pediatric Blood & Cancer·Kevin M CampbellSteven G DuBois

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