Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination

JAMA : the Journal of the American Medical Association
Ellen WarnerSteven A Narod

Abstract

Current recommendations for women who have a BRCA1 or BRCA2 mutation are to undergo breast surveillance from age 25 years onward with mammography annually and clinical breast examination (CBE) every 6 months; however, many tumors are detected at a relatively advanced stage. Magnetic resonance imaging (MRI) and ultrasound may improve the ability to detect breast cancer at an early stage. To compare the sensitivity and specificity of 4 methods of breast cancer surveillance (mammography, ultrasound, MRI, and CBE) in women with hereditary susceptibility to breast cancer due to a BRCA1 or BRCA2 mutation. A surveillance study of 236 Canadian women aged 25 to 65 years with BRCA1 or BRCA2 mutations who underwent 1 to 3 annual screening examinations, consisting of MRI, mammography, and ultrasound at a single tertiary care teaching hospital between November 3, 1997, and March 31, 2003. On the day of imaging and at 6-month intervals, CBE was performed. Sensitivity and specificity of each of the 4 surveillance modalities, and sensitivity of all 4 screening modalities vs mammography and CBE. Each imaging modality was read independently by a radiologist and scored on a 5-point Breast Imaging Reporting and Data System scale. All lesions with ...Continue Reading

Citations

Sep 9, 2011·Radiology·Janice S SungElizabeth A Morris
Jan 24, 2014·AJR. American Journal of Roentgenology·Daniel B Kopans
Sep 21, 2013·Archives of Gynecology and Obstetrics·Kristin BosseKerstin Rhiem
Dec 22, 2007·Radiology·Simone Schrading, Christiane K Kuhl
Aug 26, 2009·Radiology·Fiona J GilbertUNKNOWN United Kingdom Magnetic Resonance Imaging in Breast Screening (MARIBS) Study Group
Aug 8, 2008·Future Oncology·Vineeta SinghAnita Bourke
Aug 28, 2012·Radiology·Bruce J HillmanLawrence J Moss
Aug 25, 2012·Radiology·Christoph I LeeConstance D Lehman
Feb 18, 2011·Radiology·Janice S SungD David Dershaw
Feb 7, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Petrina A CauserDonald B Plewes
Feb 26, 2014·Breast Cancer Research and Treatment·Inge-Marie ObdeijnMadeleine M A Tilanus-Linthorst
Apr 24, 2012·Radiology·Emmanuelle Bouic PagesPatrice Taourel
Mar 29, 2014·BMC Cancer·Joanne KotsopoulosSteven A Narod
Apr 2, 2014·Breast Cancer Research and Treatment·D Gareth EvansDuffy Stephen
Nov 3, 2010·Annual Review of Medicine·Katherine L Nathanson, Susan M Domchek
Oct 12, 2013·Journal of Genetic Counseling·D KegelaersB Blaumeiser
Oct 23, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Pedro Pérez SeguraEduardo Díaz-Rubio
Mar 5, 2011·Breast Cancer Research and Treatment·Ingrid E FakkertGeertruida H de Bock
Sep 3, 2014·Breast Cancer Research and Treatment·Filippo SantoroFrancesco Sardanelli
Jul 25, 2014·Radiology·Wendie A Berg, Ellen B Mendelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.