Surveillance of drugs that most frequently induce acute kidney injury: A pharmacovigilance approach

Journal of Clinical Pharmacy and Therapeutics
Keiko HosohataKazunori Iwanaga

Abstract

Acute kidney injury (AKI) often occurs in hospitalized patients, and it is an increasing problem worldwide. Recently, clinical studies have shown that there is a strong association between drug-induced AKI and poor outcomes, including the progression of chronic kidney disease and end-stage renal disease; however, limited data are available on drug-induced AKI. The purpose of this study was to clarify the rank-order of the association of all drugs with AKI using a spontaneous reporting system database. We performed a retrospective pharmacovigilance disproportionality analysis using the Japanese Adverse Drug Event Report (JADER) database. Adverse event reports submitted to Pharmaceuticals and Medical Devices Agency between April 2004 and January 2017 were analysed. Based on 5 195 890 reports of all adverse events, we obtained 12 964 reports of AKI caused by all drugs and calculated the reporting odds ratio (ROR) and 95% confidence interval (CI) for AKI. The most frequently reported drugs were valaciclovir hydrochloride (ROR, 24.88; 95% CI: 23.1-26.8), eldecalcitol (ROR, 14.23; 95% CI, 11.68-17.33), edaravone (ROR, 14.03; 95% CI, 11.76-16.75), acyclovir (ROR, 11.17; 95% CI, 9.55-13.1), piperacillin-tazobactam (ROR, 9.23; 95% CI, 7...Continue Reading

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Citations

Sep 1, 2019·International Journal of Toxicology·Iku NiinomiKazunori Iwanaga
Sep 5, 2020·Therapeutics and Clinical Risk Management·Tomohito WakabayashiKazunori Iwanaga
Oct 23, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Zaynab ShakkourFiras Kobeissy
Nov 21, 2020·Pharmacology Research & Perspectives·Ryosuke ShinouchiKoji Nobe
May 10, 2021·Free Radical Biology & Medicine·Jean-François GoossensChristian Bailly

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