Mar 3, 2019

Surveillance of omadacycline activity tested against clinical isolates from the United States and Europe: Results from the SENTRY Antimicrobial Surveillance Programme, 2017

Journal of Global Antimicrobial Resistance
Michael D HubandRobert K Flamm

Abstract

Omadacycline is an aminomethylcycline antibacterial (oral and intravenous once-daily formulation) that recently (October 2018) received United States Food and Drug Administration (FDA) approval for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) and community-acquired bacterial pneumonia (CABP) against selected organism groups. This study tested omadacycline and comparators against 14 000 non-duplicate bacterial isolates that were prospectively collected during 2017 from medical centres in Europe (EUR; 7000 isolates) and the United States (USA; 7000 isolates). Omadacycline was tested by broth microdilution following Clinical and Laboratory Standards Institute M07-A11 (2018) methods. A total of 98.7% ofStaphylococcus aureus isolates were susceptible to omadacycline (MIC50/90, 0.12/0.25mg/L; ABSSSI breakpoints) including 96.5% of methicillin-resistant Staphylococcus aureus (MRSA), 99.8% of methicillin-susceptible Staphylococcus aureus, and 93.9% of tetracycline-resistant strains. Omadacycline activity was similar for Streptococcus pneumoniae (MIC50/90 0.06/0.12mg/L; 98.6% susceptible [CABP breakpoints]), Streptococcus anginosus group (MIC50/90 0.06/0.06mg/L; 100.0% susceptible [ABSSSI breakpoints]), ...Continue Reading

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Mentioned in this Paper

Study
Drug Formulation Process
Bacterial Proteins
Intravenous
Haemophilus influenzae
7-dimethylamino-9-(2,2-dimethylpropyl)aminomethylcycline
Klebsiella pneumoniae
Lactamase
Services, Community
Beta-Lactamase

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