Surveillance of transmitted HIV type 1 drug resistance in newly diagnosed hiv type 1-infected patients in Shandong Province, China

AIDS Research and Human Retroviruses
Jing ZhangChunfu Yang

Abstract

A survey to measure transmitted HIV-1 drug resistance (DR) was conducted in 2006 following the World Health Organization threshold survey protocol. Dried blood spots (DBS) were prepared from 53 newly HIV-1-diagnosed patients. Protease and reverse transcriptase (RT) gene regions were sequenced using a broadly sensitive genotyping assay and analyses to identify DR mutations and determine phylogeny of the HIV-1 strains were conducted. Forty-six of the 47 successfully genotyped DBS had no transmitted DR mutations; one had an NNRTI mutation (K101E) in the RT region. Phylogenetic analyses revealed 21 (44.7%) were CRF01_AE, 9 (19.1%) B, 6 (12.8%) CRF07_BC, 3 (6.4%) each of CRF08_BC and C, and 2 (4.3%) B/C unique recombinant forms (URF). The remaining three were one each of A/B, A/C, and unclassifiable. Our analyses indicate that the prevalence of transmitted DR in this population is low and the HIV-1 epidemic in the area was characterized by multiple subtypes and recombinant forms.

References

Dec 15, 2006·Journal of Clinical Microbiology·Amanda McNultyJ Gerardo García-Lerma
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar

❮ Previous
Next ❯

Citations

May 11, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lingjie LiaoYiming Shao
Jul 12, 2011·The Journal of School Health·Soledad Liliana Escobar-ChavesSusan Tortolero
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·Bethany L HedtTed Cohen
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erin K RottinghausChunfu Yang
Jul 11, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Silvina MasciotraDennis Ellenberger
Nov 3, 2011·Transfusion·Peibin ZengUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component
Jul 8, 2016·SpringerPlus·Chenhao QinHong Du

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

ChromasPro
BioEdit
CLUSTAL W
MEGA
DNADIST

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Richard UgbenaChunfu Yang
The New England Journal of Medicine
Myron S CohenBarton F Haynes
Nature Reviews. Genetics
Andrew RambautEdward C Holmes
© 2021 Meta ULC. All rights reserved