PMID: 8598511Jan 1, 1996Paper

Surveillance of vaccine-related adverse events in the first year of life: a Manitoba cohort study

Journal of Clinical Epidemiology
J D RobertsB Law

Abstract

This study used data from the population database through which the province of Manitoba, Canada, administers its universal health insurance plan. Enrollment, hospitalization, and immunization files from children born in the 1987-1989 period were linked using the unique identification number assigned to each population member. Analysis of these linked data successfully identified serious potential adverse events in the first year of life and the timing of events around immunization. Not only is population-based active surveillance for immunization-related events feasible, but the techniques described, applied to years of data accumulated through surveillance, offer powerful research tools. Baseline population incidences of adverse events were calculated, temporal relationships between events and immunization assessed, and incidences for events showing true temporal associations determined. Eventual goals are the quantification of vaccine-related risk and the gathering of evidence concerning casual associations. The approach could be used readily by several other Canadian provinces and by health maintenance organizations in the United States.

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Citations

Dec 3, 1996·Healthcare Management Forum·L L RoosM M Cohen
Feb 11, 1999·Journal of Clinical Epidemiology·L L Roos, J P Nicol
Sep 8, 2001·The New England Journal of Medicine·W E BarlowUNKNOWN Centers for Disease Control and Prevention Vaccine Safety Datalink Working Group
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katrin S KohlUNKNOWN Brighton Collaboration Fever Working Group
Aug 18, 2000·Paediatric Drugs·R T ChenF DeStefano
Jan 8, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Salaheddin M MahmudAlain A Demers
May 12, 2017·Human Vaccines & Immunotherapeutics·Salaheddin M MahmudSongul Bozat-Emre
Jul 25, 1998·Pediatric Annals·R T Chen, B Hibbs
Oct 31, 1997·Medical Decision Making : an International Journal of the Society for Medical Decision Making·T WiebeL L Roos
Sep 28, 2017·Human Vaccines & Immunotherapeutics·Jennifer Potter, Salaheddin M Mahmud

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