Survey and analysis of crystal polymorphism in organic structures

IUCrJ
Kortney KerstenAdam Matzger

Abstract

With the intention of producing the most comprehensive treatment of the prevalence of crystal polymorphism among structurally characterized materials, all polymorphic compounds flagged as such within the Cambridge Structural Database (CSD) are analysed and a list of crystallographically characterized organic polymorphic compounds is assembled. Classifying these structures into subclasses of anhydrates, salts, hydrates, non-hydrated solvates and cocrystals reveals that there are significant variations in polymorphism prevalence as a function of crystal type, a fact which has not previously been recognized in the literature. It is also shown that, as a percentage, polymorphic entries are decreasing temporally within the CSD, with the notable exception of cocrystals, which continue to rise at a rate that is a constant fraction of the overall entries. Some phenomena identified that require additional scrutiny include the relative prevalence of temperature-induced phase transitions among organic salts and the paucity of polymorphism in crystals with three or more chemical components.

References

Jul 28, 2001·Pharmaceutical Research·J BauerJ Morris
Feb 14, 2004·Advanced Drug Delivery Reviews·Barbara Rodríguez-SpongNaír Rodríguez-Hornedo
Sep 28, 2005·Acta Crystallographica. Section B, Structural Science·Jacco van de Streek, Sam Motherwell
Aug 24, 2007·Chemical Communications : Chem Comm·Prashant M Bhatt, Gautam R Desiraju
Jul 16, 2009·Journal of Pharmaceutical Sciences·Katie M Lutker, Adam J Matzger
Feb 1, 2011·Journal of Pharmaceutical Sciences·Katie M LutkerAdam J Matzger
May 20, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Vilmalí López-MejíasAdam J Matzger
Sep 9, 2011·Angewandte Chemie·Onas Bolton, Adam J Matzger
Jun 14, 2012·Journal of the American Chemical Society·Vilmalí López-MejíasAdam J Matzger
Jun 17, 2014·ACS Combinatorial Science·Laura Y Pfund, Adam J Matzger
Sep 25, 2015·Chemical Society Reviews·Aurora J Cruz-CabezaJoel Bernstein
Mar 2, 2016·Chemical Communications : Chem Comm·Saikat RoyAdam J Matzger
Mar 24, 2016·Chemical Communications : Chem Comm·Kortney M Kersten, Adam J Matzger
Apr 7, 2016·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Colin R GroomSuzanna C Ward
May 6, 2015·Crystal Growth & Design·Laura Y PfundAdam J Matzger

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Citations

Nov 7, 2019·Chemical Communications : Chem Comm·Filip TopićTomislav Friščić
Aug 25, 2020·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·German Perlovich, Artem Surov
Sep 6, 2020·Acta Crystallographica. Section C, Structural Chemistry·Jetnipat SongkerdthongDavid J Harding
Aug 28, 2020·Acta Crystallographica. Section E, Crystallographic Communications·Fermin Flores ManuelSylvain Bernès
Apr 13, 2021·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Ivica Cvrtila, Vladimir Stilinović
Oct 8, 2020·Accounts of Chemical Research·Alice HeskiaJames D Wuest
Jun 9, 2020·Journal of the American Chemical Society·Alexandre LévesqueJames D Wuest
Jun 28, 2019·Chemical Reviews·Robin Taylor, Peter A Wood
Oct 6, 2021·Acta Crystallographica. Section C, Structural Chemistry·Seik Weng Ng

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ConQuest

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