Survey of cord blood hemoglobin in Japan and identification of two new gamma chain variants

Hemoglobin
K FuyunoT Miyaji

Abstract

Two gamma chain variants were discovered during a survey of 2,569 cord bloods of Japanese. One was the first case with mutation of the T-gamma chain, i. e. Hb F Yamaguchi or gamma 80 (EF 4) Asp leads to Asn (75 Thr, 136 Ala). It comprised 33.6% of Hb F, an unusually high percentage for a gamma chain variant. The other concerned with the first report of substitution at E 16, i. e. Hb F Iwata or gamma 72 (E 16) Gly leads to Arg (75 Ile, 136 Ala). It comprised 11.0% which is comparable to the values usually reported in an A-gamma chain variant. No clinical consequences have been observed in association with the hemoglobin variants.

References

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Feb 1, 1979·The Journal of Clinical Investigation·W A SchroederH Lam
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Mar 20, 1930·The Journal of General Physiology·M L Anson, A E Mirsky

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Citations

Mar 11, 2004·Hemoglobin·Denise Faustino DuarteMaria de Fátima Sonati
Jan 1, 1982·Hemoglobin·J B SheltonD Powars
Apr 1, 1983·American Journal of Hematology·T NakatsujiT H Huisman
Jul 1, 1997·American Journal of Hematology·T H Huisman
Feb 1, 1984·American Journal of Hematology·T NakatsujiT H Huisman
Jan 1, 1989·Hemoglobin·K HidakaG Iwakawa

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