PMID: 9421106Jan 8, 1998Paper

Survey of cyclosporine therapeutic ranges, assay methodology, and use of 'sparing agents' in Australasian transplant centers

Therapeutic Drug Monitoring
T E Jones, R G Morris

Abstract

Since its introduction in the 1980s, cyclosporine has become the major immunosuppressive drug used in organ transplantation. Despite widespread experience with this expensive agent, a number of controversial issues remain. These include the use of sparing agents to allow a lower dose of cyclosporine to be prescribed, specificity of assay method, and values quoted as therapeutic ranges. The authors surveyed organ transplant centers in Australia and New Zealand to ascertain local practices and found considerable variability in the use and dosage of sparing agents, cyclosporine assay method, and therapeutic ranges. The implications of these differences are discussed.

References

Jan 1, 1992·British Journal of Clinical Pharmacology·J DreweT Kissel
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Apr 1, 1989·Lancet·U KunzendorfG Offerman
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Nov 1, 1996·British Journal of Clinical Pharmacology·T E Jones, R G Morris
Dec 1, 1996·Australian and New Zealand Journal of Medicine·T E Jones

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Citations

Sep 7, 2001·Transplantation Proceedings·S A Jensen, K P Dalhoff
Apr 25, 2000·Therapeutic Drug Monitoring·R G Morris
Jul 27, 2002·Therapeutic Drug Monitoring·Raymond G Morris, Ada K Lam
Nov 27, 2002·Therapeutic Drug Monitoring·Raymond G MorrisStephen Cook
Dec 23, 1998·British Journal of Clinical Pharmacology·R G MorrisB C Sallustio

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